Evidence map›Paper›PMID 39158301›Full record

ReviewClinical microbiology reviews2024

Practical Guidance for Clinical Microbiology Laboratories: Updated guidance for processing respiratory tract samples from people with cystic fibrosis.

Lisa Saiman, Valerie Waters, John J LiPuma, Lucas R Hoffman, Kevin Alby, Sean X Zhang, Yvonne C Yau, Damian G Downey, Isabelle Sermet-Gaudelus, Jean-Philippe Bouchara and 3 more

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Article
  3. A Pilot Study ofDiagnostics (Basel, Switzerland) · 2026
    Article
  4. Clinical and microbiological characteristics of pediatricFrontiers in cellular and infection microbiology · 2026
    Article
  5. Microbial and host innate immune factors affecting the persistence ofFrontiers in cellular and infection microbiology · 2026
    Review
  6. Observational
  7. Home sputum collection forERJ open research · 2025
    Article
  8. Article
  9. Epidemiological and Clinical Characteristics ofTropical medicine and infectious disease · 2025
    Article
  10. Article
  11. Cystic Fibrosis Year in Review 2024.Pediatric pulmonology · 2025
    Review
  12. State-of-the-Art Review: Transformative Changes in the Care of People With Cystic Fibrosis: Implications for Infectious Diseases Specialists.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Review
  13. Microorganisms · 2025
    Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lisa SaimanDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-7231-8451
Valerie WatersDivision of Infectious Diseases, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-1566-6510
John J LiPumaDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0003-4033-7794
Lucas R HoffmanDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Kevin AlbyDepartment of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Sean X ZhangDivision of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1166-2563
Yvonne C YauDivision of Microbiology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Damian G DowneyWellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, Ireland.
Isabelle Sermet-GaudelusUniversité de Paris Cité, Hôpital Necker-Enfants Malades, Assistance Publique, Paris, France.
Jean-Philippe BoucharaUniversity of Angers-University of Brest, Infections Respiratoires Fongiques, Angers, France.
Timothy J KiddMicrobiology Division, Pathology Queensland Central Laboratory, The University of Queensland, Brisbane, Australia.
Scott C BellThe Prince Charles Hospital, Faculty of Medicine, The University of Queensland, Brisbane, Australia.ORCID 0000-0001-8651-7139
A Whitney BrownCystic Fibrosis Foundation, Bethesda, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SUMMARYThis guidance presents recommendations for clinical microbiology laboratories for processing respiratory samples from people with cystic fibrosis (pwCF). Appropriate processing of respiratory samples is crucial to detect bacterial and fungal pathogens, guide treatment, monitor the epidemiology of cystic fibrosis (CF) pathogens, and assess therapeutic interventions. Thanks to CF transmembrane conductance regulator modulator therapy, the health of pwCF has improved, but as a result, fewer pwCF spontaneously expectorate sputum. Thus, the collection of sputum samples has decreased, while the collection of other types of respiratory samples such as oropharyngeal and bronchoalveolar lavage samples has increased. To optimize the detection of microorganisms, including

Indexed as

Cystic FibrosisRespiratory Tract InfectionsSpecimen HandlingBacteriaFungiHumansMicrobiological TechniquesRespiratory Systemcystic fibrosisMALDI-TOF MSpathogen identificationrespiratory pathogenssmall colony variantssusceptibility testing

Identifiers

PMID39158301
PMCPMC11391703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.