Evidence map›Paper›PMID 39158295›Full record

ArticleAntimicrobial agents and chemotherapy2024

Systemic absorption and safety of topical terbinafine hydrochloride 10% solution (MOB015B): a phase 1 maximal usage trial in patients with moderate-to-severe onychomycosis.

Amir Tavakkol, Janet C DuBois, Aditya K Gupta

Registry-linked trialAbstract readClinical Trial, Phase I
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03244280 (A Study of the Systemic Absorption of Once Daily MOB015B When Applied for 28 Days in Subjects With Moderate to Severe Onychomycosis of the Toenails.), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03244280 phase1completednot on this map

A Study of the Systemic Absorption of Once Daily MOB015B When Applied for 28 Days in Subjects With Moderate to Severe Onychomycosis of the Toenails.

TypeinterventionalSponsorMoberg Pharma ABRan2017 to 2018Enrolled20ConditionsOnychomycosisArmsMOB015B
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antifungal Dispensing in Denmark: Patterns Across Primary Care, Secondary Care, and Over-the-Counter Sectors.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amir TavakkolMoberg Pharma AB, Bromma, Sweden.ORCID 0009-0001-9627-203X
Janet C DuBoisDermResearch Inc., Austin, Texas, USA.
Aditya K GuptaDivision of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8664-7723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Topical antifungals may be considered to treat onychomycosis with minimal risk of systemic side effects. In this study, we assess the safety, tolerability, systemic exposure, and pharmacokinetic characteristics of topical terbinafine hydrochloride 10% solution (MOB015B) in adults with moderate-to-severe onychomycosis. Clinically and mycologically confirmed patients with toenail onychomycosis ( CLINICAL TRIALS: This study is registered with ClinicalTrials.gov as NCT03244280.

Indexed as

Administration, TopicalAntifungal AgentsOnychomycosisTerbinafineAdultAgedFemaleHumansMaleMiddle AgedNaphthalenesAntifungal AgentsNaphthalenesTerbinafineonychomycosispharmacokineticsterbinafine

Identifiers

PMID39158295
PMCPMC11459961

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.