Evidence map›Paper›PMID 39157593›Full record

ArticleEJHaem2024

Weight loss and dysgeusia in relapsed/refractory multiple myeloma patients treated with talquetamab.

Syed Naqvi, Asis Shrestha, Marah Alzubi, Jawad Alrawabdeh, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Carolina Schinke, Samer Al Hadidi

Erratum issuedAbstract read
In one paragraph

Article in EJHaem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Gustatory dysfunction under talquetamab therapy in multiple myeloma: a cross-sectional study of patient-reported course, nutritional changes, and quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Review
  3. Dermatologic Adverse Events Associated with T-Cell Engager Therapy.American journal of clinical dermatology · 2026
    Review
  4. Supportive care for talquetamab-related dysgeusia in multiple myeloma: mixed-methods evidence, nutrition-focused flowchart, and digital companion concept.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  5. On-target, off-tumor oral toxicities of talquetamab in heavily pretreated multiple myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Syed NaqviMyeloma Center University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Asis ShresthaMyeloma Center University of Arkansas for Medical Sciences Little Rock Arkansas USA.ORCID https://orcid.org/0000-0003-2411-0514
Marah AlzubiDepartment of Internal Medicine University of Jordan Amman Jordan.ORCID https://orcid.org/0000-0002-0531-918X
Jawad AlrawabdehDepartment of Internal Medicine University of Jordan Amman Jordan.ORCID https://orcid.org/0000-0002-4127-5102
Sharmilan ThanendrarajanMyeloma Center University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Maurizio ZangariMyeloma Center University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Frits van RheeMyeloma Center University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Carolina SchinkeMyeloma Center University of Arkansas for Medical Sciences Little Rock Arkansas USA.
Samer Al HadidiMyeloma Center University of Arkansas for Medical Sciences Little Rock Arkansas USA.ORCID https://orcid.org/0000-0003-4297-8042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Talquetamab is an approved therapy for relapsed multiple myeloma. This study examined dysgeusia and weight loss occurrences, alongside investigating symptom reversibility post-treatment cessation. Dysgeusia was prevalent, persisting in 15% of patients. On average, patients lost 6% of their weight during treatment, with weight loss persisting in about half of the patients post-discontinuation. Weight loss and dysgeusia are important adverse events to consider while on talquetamab treatment. Extending dose intervals can potentially prevent such adverse events and should be studied in future prospective clinical trials.

Indexed as

dysgeusiamultiple myelomatalquetamabweight loss

Identifiers

PMID39157593
PMCPMC11327703

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.