Evidence map›Paper›PMID 39157294›Full record

ArticlePhysics and imaging in radiation oncology2024

Correlation between local instantaneous dose rate and oxygen pressure reduction during proton pencil beam scanning irradiation.

Eleni Kanouta, Jacob Graversen Johansen, Sara Poulsen, Line Kristensen, Brita Singers Sørensen, Cai Grau, Morten Busk, Per Rugaard Poulsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eleni KanoutaDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Jacob Graversen JohansenDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Sara PoulsenDepartment of Physics and Astronomy, Aarhus University, Aarhus, Denmark.
Line KristensenDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Brita Singers SørensenDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Cai GrauDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Morten BuskDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Per Rugaard PoulsenDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Oxygen dynamics may be important for the tissue-sparing effect observed at ultra-high dose rates (FLASH sparing effect). This study investigated the correlation between local instantaneous dose rate and radiation-induced oxygen pressure reduction during proton pencil beam scanning (PBS) irradiations of a sample and quantified the oxygen consumption g-value. Materials and methods: A 0.2 ml phosphorescent sample (1 μM PtG4 Oxyphor probe in saline) was irradiated with a 244 MeV proton PBS beam. Four irradiations were performed with variations of a PBS spot pattern with 5 × 7 spots. During irradiation, the partial oxygen pressure (pO Results: A high correlation was found between the local instantaneous dose rate and pO Conclusions: The pO

Indexed as

Oxygen consumption g-valueOxygen dynamicsPhosphorescence quenchingProton pencil beam scanning

Identifiers

PMID39157294
PMCPMC11327481

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.