Evidence map›Paper›PMID 39157118›Full record

ArticleACS omega2024

Enhancing Immune Responses against SARS-CoV-2 Variants in Aged Mice with INDUK: A Chimeric DNA Vaccine Encoding the Spike S1-TM Subunits.

Lishan Cui, Junbiao Wang, Fiorenza Orlando, Robertina Giacconi, Marco Malavolta, Beatrice Bartozzi, Roberta Galeazzi, Giorgia Giorgini, Luca Pesce, Francesco Cardarelli and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Lishan CuiSchool of Biosciences and Veterinary Medicine, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy.ORCID https://orcid.org/0000-0001-7647-1376
Junbiao WangSchool of Biosciences and Veterinary Medicine, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy.
Fiorenza OrlandoExperimental Animal Models for Aging Unit, Scientific Technological Area, IRRCS INRCA, 60100 Ancona, Italy.
Robertina GiacconiAdvanced Technology Center for Aging Research, IRCCS INRCA, 60100Ancona, Italy.
Marco MalavoltaAdvanced Technology Center for Aging Research, IRCCS INRCA, 60100Ancona, Italy.
Beatrice BartozziAdvanced Technology Center for Aging Research, IRCCS INRCA, 60100Ancona, Italy.
Roberta GaleazziDepartment of Life and Environmental Sciences, Marche Polytechnic University, 60131 Ancona, Italy.
Giorgia GiorginiDepartment of Life and Environmental Sciences, Marche Polytechnic University, 60131 Ancona, Italy.
Luca PesceNEST Laboratory, Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy.
Francesco CardarelliNEST Laboratory, Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy.ORCID https://orcid.org/0000-0003-3049-5940
Erica QuagliariniNanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, viale Regina Elena 291, 00161 Rome, Italy.
Serena RenziNanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, viale Regina Elena 291, 00161 Rome, Italy.
Siyao XiaoNanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, viale Regina Elena 291, 00161 Rome, Italy.
Daniela PozziNanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, viale Regina Elena 291, 00161 Rome, Italy.
Mauro ProvincialiExperimental Animal Models for Aging Unit, Scientific Technological Area, IRRCS INRCA, 60100 Ancona, Italy.
Giulio CaraccioloNanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, viale Regina Elena 291, 00161 Rome, Italy.ORCID https://orcid.org/0000-0002-8636-4475
Cristina MarchiniSchool of Biosciences and Veterinary Medicine, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy.ORCID https://orcid.org/0000-0001-7692-8428
Augusto AmiciSchool of Biosciences and Veterinary Medicine, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently available vaccines against COVID-19 showed high efficacy against the original strain of SARS-CoV-2 but progressively lower efficacy against new variants. In response to emerging SARS-CoV-2 strains, we propose chimeric DNA vaccines encoding the spike antigen, including a combination of selected key mutations from different variants of concern. We developed two DNA vaccines, pVAX-S1-TM-D614G and pVAX-S1-TM-INDUK (INDUK), encoding the SARS-CoV-2 S1 spike subunit in fusion with the transmembrane region that allows protein trimerization as predicted by

Identifiers

PMID39157118
PMCPMC11325517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.