Evidence map›Paper›PMID 39156920›Full record

ReviewCurrent epidemiology reports2024

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective.

Mandy Fisher, Hope A Weiler, Jordan R Kuiper, Michael Borghese, Jessie P Buckley, Robin Shutt, Jillian Ashley-Martin, Anita Subramanian, Tye E Arbuckle, Beth K Potter and 3 more

Abstract readReview
In one paragraph

Review in Current epidemiology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mandy FisherEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON Canada.
Hope A WeilerNutrition Research Division, Health Products and Food Branch, Health Canada, Ottawa, ON Canada.
Jordan R KuiperMilken Institute School of Public Health, The George Washington University, Washington, DC USA.
Michael BorgheseEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON Canada.
Jessie P BuckleyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Gillings School of Global Public Health Sciences, Chapel Hill, North Carolina USA.
Robin ShuttEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON Canada.
Jillian Ashley-MartinEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON Canada.
Anita SubramanianNational Institute of Environmental Health Sciences (NIEHS), Duram, North Carolina USA.
Tye E ArbuckleEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON Canada.
Beth K PotterSchool of Epidemiology and Public Health (SEPH), University of Ottawa, Ottawa, ON Canada.
Julian LittleSchool of Epidemiology and Public Health (SEPH), University of Ottawa, Ottawa, ON Canada.
Anne-Sophie MorissetSchool of Nutrition, Laval Université, Quebec, QC Canada.
Anne Marie JukicNational Institute of Environmental Health Sciences (NIEHS), Duram, North Carolina USA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Purpose of Review: To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women. Recent Findings: We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings. Summary: Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals. Supplementary Information: The online version contains supplementary material available at 10.1007/s40471-024-00348-0.

Indexed as

ArsenicCadmiumLeadMercuryMetalsPbPregnancyVitamin D

Identifiers

PMID39156920
PMCPMC11329583

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.