Evidence map›Paper›PMID 39156890›Full record

ArticleFrontiers in immunology2024

Role of glycosylation-related gene MGAT1 in pancreatic ductal adenocarcinoma.

Lai Jiang, Jie Liu, Shengke Zhang, Chenglu Jiang, Jinbang Huang, Haiqing Chen, Xuancheng Zhou, Yiping Fu, Zhongqiu Yang, Rui Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
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  7. Review
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  9. Article
  10. TSPAN4Frontiers in immunology · 2025
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  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Integrating multi-omics techniques andFrontiers in immunology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lai Jiang *Clinical Medical College, Southwest Medical University, Luzhou, China.
Jie Liu *Department of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Shengke Zhang *Clinical Medical College, Southwest Medical University, Luzhou, China.
Chenglu Jiang *Clinical Medical College, Southwest Medical University, Luzhou, China.
Jinbang HuangClinical Medical College, Southwest Medical University, Luzhou, China.
Haiqing ChenClinical Medical College, Southwest Medical University, Luzhou, China.
Xuancheng ZhouClinical Medical College, Southwest Medical University, Luzhou, China.
Yiping FuClinical Medical College, Southwest Medical University, Luzhou, China.
Zhongqiu YangDepartment of General Surgery, Dazhou Central Hospital, Dazhou, China.
Rui WangDepartment of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Guanhu YangDepartment of Specialty Medicine, Ohio University, Athens, OH, United States.
Hao ChiClinical Medical College, Southwest Medical University, Luzhou, China.
Bo LiDepartment of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a very poor prognosis and a complex tumor microenvironment, which plays a key role in tumor progression and treatment resistance. Glycosylation plays an important role in processes such as cell signaling, immune response and protein stability. Materials and methods: single-cell RNA sequencing data and spatial transcriptome data were obtained from GSE197177 and GSE224411, respectively, and RNA-seq data and survival information were obtained from UCSC Xena and TCGA. Multiple transcriptomic data were comprehensively analyzed to explore the role of glycosylation processes in tumor progression, and functional experiments were performed to assess the effects of MGAT1 overexpression on PDAC cell proliferation and migration. Results: In PDAC tumor samples, the glycosylation level of macrophages was significantly higher than that of normal samples. MGAT1 was identified as a key glycosylation-related gene, and its high expression was associated with better patient prognosis. Overexpression of MGAT1 significantly inhibited the proliferation and migration of PDAC cells and affected intercellular interactions in the tumor microenvironment. Conclusion: MGAT1 plays an important role in PDAC by regulating glycosylation levels in macrophages, influencing tumor progression and improving prognosis.MGAT1 is a potential therapeutic target for PDAC and further studies are needed to develop targeted therapeutic strategies against MGAT1 to improve clinical outcomes.

Indexed as

Carcinoma, Pancreatic DuctalCell MovementCell ProliferationGene Expression Regulation, NeoplasticPancreatic NeoplasmsTumor MicroenvironmentBiomarkers, TumorCell Line, TumorGlycosylationHumansMacrophagesPrognosisBiomarkers, Tumorglycosylationglycosyltransferaseimmunotherapymacrophagespredictive markersingle-cell analysis

Identifiers

PMID39156890
PMCPMC11328014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.