Evidence map›Paper›PMID 39156722›Full record

ArticleBiochemistry and biophysics reports2024

Generation of bone-specific lysyl hydroxylase 2 knockout mice and their phenotypes.

Kenta Tsuneizumi, Atsushi Kasamatsu, Tomoaki Saito, Reo Fukushima, Yuki Taga, Kazunori Mizuno, Masataka Sunohara, Katsuhiro Uzawa, Mitsuo Yamauchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Genome-Wide Analysis of Copy Number Variation in Vietnamese Local Chickens.Animals : an open access journal from MDPI · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kenta TsuneizumiDepartment of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
Atsushi KasamatsuDepartment of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan.
Tomoaki SaitoDepartment of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
Reo FukushimaDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Yuki TagaNippi Research Institute of Biomatrix, Ibaraki, Japan.
Kazunori MizunoNippi Research Institute of Biomatrix, Ibaraki, Japan.
Masataka SunoharaDepartment of Anatomy, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan.
Katsuhiro UzawaDepartment of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
Mitsuo YamauchiDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of type I collagen. This modification is critical for the formation of stable hydroxylysine-aldehyde derived collagen cross-links, thus, for the stability of collagen fibrils. Though dysfunction of LH2 causes Bruck syndrome, recessive osteogenesis imperfecta with joint contracture, the molecular mechanisms by which LH2 affects bone formation are still not well understood. Since the

Indexed as

Bone-specific conditional knockoutCollagen cross-linkLysyl hydroxylase 2

Identifiers

PMID39156722
PMCPMC11327825

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.