Evidence map›Paper›PMID 39156699›Full record

ArticleFrontiers in oncology2024

Fully-automated production of [

Binchen Wang, Yaqun Jiang, Jiaxu Zhu, Huiqin Wu, Jianyuan Wu, Ling Li, Jianying Huang, Zhiwei Xiao, Yong He

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05835570 (A Single-arm, Open-label, Single-center Clinical Study to the Evaluation of Integrin αvβ6-targeted Positron Emission Tomography), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05835570 recruitingnot on this map

A Single-arm, Open-label, Single-center Clinical Study to the Evaluation of Integrin αvβ6-targeted Positron Emission Tomography (PET) for Malignant Tumors

TypeobservationalSponsorZhongnan HospitalRan2023 to 2025Enrolled200ConditionsMalignant Neoplasm, PET/CT, Non-Small Cell Lung Cancer, Breast Cancer, MetastaticArmsPET/CT scans
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Integrin αvβ6-Targeted PET/CT Imaging of Non-Small Cell Lung Cancer with [Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Observational
  2. [European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Cancers · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Binchen Wang *Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yaqun Jiang *Clinical Trial Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jiaxu ZhuDepartment of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Huiqin WuDepartment of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jianyuan WuClinical Trial Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Ling LiDepartment of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jianying HuangClinical Trial Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhiwei XiaoDepartment of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yong HeDepartment of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The α Methods: The pH value and the precursor load of radiolabeling were explored using an iQS-TS fully-automated module. Radiochemical purity was evaluated by radio-HPLC and radio-TLC. The ethanol content, radionuclide purity and identity, bacterial endotoxins, sterility, and stability of the final product [ Results: The synthesis was explored and established using fully-automated module with outstanding radiochemical purity (>99%). Considering molar activity and economic costs, a pH of 3.6 and precursor dose of 30 μg were determined to be optimal. All relevant quality control parameters were tested and met the requirement of European Pharmacopoeia. Conclusions: A fully-automated synthesis protocol for [ Clinical trial registration: ClinicalTrials.gov, NCT05835570. Registered 28 April 2023, https://www.clinicaltrials.gov/study/NCT05835570.

Indexed as

biodistributionfully-automatedPETTrivehexinαvβ6-integrin

Identifiers

PMID39156699
PMCPMC11327152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.