Evidence map›Paper›PMID 39156653›Full record

ArticleiScience2024

MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway.

Bingsi Tang, Jiangfan Yu, Rui Tang, Xinglan He, Jiani Liu, Licong Liu, Zehong Song, Yaqian Shi, Zhuotong Zeng, Yi Zhan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bingsi TangDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Jiangfan YuDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Rui TangDepartment of Rheumatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Xinglan HeDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Jiani LiuDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Licong LiuDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Zehong SongDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Yaqian ShiDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Zhuotong ZengDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Yi ZhanDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Xiangning QiuDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Yangfan XiaoClinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.
Yan DingDepartment of Dermatology, Hainan Provincial Hospital of Skin Disease, Haikou, Hainan 570100, China.
Rong XiaoDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic sclerosis (SSc) is an autoimmune disease affecting multiple tissues. The underlying causes and mechanisms of subcutaneous adipose tissue (SAT) loss in SSc remain unclear. Recent studies have highlighted the role of microRNAs in adipogenesis. Our study found that miR-4769-3p was upregulated in SSc patients and its silencing promoted SAT recovery in bleomycin-induced SSc mice, suggesting that miR-4769-3p might affect adipogenesis in SSc. Manipulating miR-4769-3p expression in 3T3-L1 cells revealed that its inhibition enhanced adipogenesis, while its overexpression weakened it. Further investigations showed that miR-4769-3p bound to 3'UTR of ubiquitin-specific protease-18 (USP18), inhibiting its expression, while USP18 interacted with voltage-dependent anion channel-2 (VDAC2), both of which were reduced in SSc. Silencing either USP18 or VDAC2 attenuated adipogenesis. Notably, USP18 inhibited VDAC2 ubiquitination and degradation, whereas miR-4769-3p reversed the VDAC2-induced elevation of adipogenesis, suggesting that miR-4769-3p inhibited adipogenesis by negatively regulating the USP18/VDAC2 pathway, providing a potential therapeutic target for SSc.

Indexed as

Cell biologyMolecular biology

Identifiers

PMID39156653
PMCPMC11326926

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.