Evidence map›Paper›PMID 39156649›Full record

ArticleiScience2024

Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study.

Ralph-Sydney Mboumba Bouassa, Giada Giorgini, Cristoforo Silvestri, Chanté Muller, Nayudu Nallabelli, Yulia Alexandrova, Madeleine Durand, Cécile Tremblay, Mohamed El-Far, Carl Chartrand-Lefebvre and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ralph-Sydney Mboumba BouassaDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Quebec à Montréal, Montreal, QC, Canada.
Giada GiorginiResearch Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval.
Cristoforo SilvestriResearch Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval.
Chanté MullerResearch Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval.
Nayudu NallabelliResearch Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval.
Yulia AlexandrovaDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Quebec à Montréal, Montreal, QC, Canada.
Madeleine DurandCentre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada.
Cécile TremblayCentre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada.
Mohamed El-FarCentre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada.
Carl Chartrand-LefebvreCentre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada.
Marc Messier-PeetCentre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada.
Shari MargoleseCIHR Canadian HIV Trials Network (CTN), Vancouver, BC, Canada.
Nicolas FlamandResearch Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval.
Cecilia T CostiniukInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Vincenzo Di MarzoResearch Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval.
Mohammad-Ali JenabianDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Quebec à Montréal, Montreal, QC, Canada.

Funding

Role of IL-32 as a predictor and mediator of Premature Aging Phenotypes(PAP) in HIV infection.R01AG054324 · NIA · CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (UNIVERSITY OF MONTREAL HOSPITAL) · PI TREMBLAY, CECILE · 2016 to 2025
$4.2M
NIA NIH HHS R01 AG054324
6 · The paper itself

Abstract

Chronic HIV infection is associated with accelerated coronary artery disease (CAD) due to chronic inflammation. The expanded endocannabinoid system (eCBome) and gut microbiota modulate each other and are key regulators of cardiovascular functions and inflammation. We herein investigated the interplay between plasma eCBome mediators and gut microbiota in people with HIV (PWH) and/or subclinical CAD versus HIV-uninfected individuals. CAD was determined by coronary computed tomography (CT) angiography performed on all participants. Plasma eCBome mediator and fecal microbiota composition were assessed by tandem mass spectrometry and 16S rDNA sequencing, respectively. HIV infection was associated with perturbed plasma eCBome mediators characterized by an inverse relationship between anandamide and

Indexed as

Cardiovascular medicineHealth sciencesImmunologyMedical specialtyMedicine

Identifiers

PMID39156649
PMCPMC11326910

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.