Evidence map›Paper›PMID 39155967›Full record

SynthesisF1000Research2024

Extracellular matrix of lung scaffolds submitted to different means of sterilization: a systematic review.

Ricardo S Moura, Joao Pedro R Afonso, Adriano L Fonseca, Andressa D Cereta, Diego A C P G Mello, Miria C Oliveira, Iransé Oliveira-Silva, Rodrigo F Oliveira, Deise A A P Oliveira, Rodolfo P Vieira and 3 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in F1000Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ricardo S MouraCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Joao Pedro R AfonsoCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Adriano L FonsecaCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Andressa D CeretaDepartament of Surgery, Faculty of Veterinary Medicine and Animal Science - University of São Paulo, São Paulo, São Paulo, Brazil.
Diego A C P G MelloCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Miria C OliveiraCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Iransé Oliveira-SilvaCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Rodrigo F OliveiraCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Deise A A P OliveiraCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Rodolfo P VieiraCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Renata K PalmaCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.
Giuseppe InsalacoInstitute of Translational Pharmacology, National Research Council - CNR, Palermo, SI, Italy.
Luis Vicente Franco OliveiraCell Culture Laboratory, Evangelical University of Goiás - UniEVANGELICA, Anapolis, Goias, 75075-580, Brazil.ORCID https://orcid.org/0000-0002-3852-9415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic respiratory diseases often necessitate lung transplantation due to irreversible damage. Organ engineering offers hope through stem cell-based organ generation. However, the crucial sterilization step in scaffold preparation poses challenges. This study conducted a systematic review of studies that analysed the extracellular matrix (ECM) conditions of decellularised lungs subjected to different sterilisation processes. A search was performed for articles published in the PubMed, Web of Sciences, Scopus, and SciELO databases according to the PRISMA guidelines. Overall, five articles that presented positive results regarding the effectiveness of the sterilisation process were selected, some of which identified functional damage in the ECM. Was possible concluded that regardless of the type of agent used, physical or chemical, all of them demonstrated that sterilisation somehow harms the ECM. An ideal protocol has not been found to be fully effective in the sterilisation of pulmonary scaffolds for use in tissue and/or organ engineering.

Indexed as

Extracellular MatrixLungSterilizationTissue ScaffoldsAnimalsHumansTissue EngineeringDecellularizationExtracellular matrixRecellularizationScaffoldsStem cellsSterilization

Identifiers

PMID39155967
PMCPMC11329863

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.