Evidence map›Paper›PMID 39155655›Full record

ArticleDrug and chemical toxicology2025

Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract.

Laura E Ewing, Charles M Skinner, Mitchell R McGill, Stefanie Kennon-McGill, Kirsten Clement, Charles M Quick, Eric U Yee, D Keith Williams, Larry A Walker, Mahmoud A ElSohly and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and chemical toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Laura E EwingDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Charles M SkinnerDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mitchell R McGillDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Stefanie Kennon-McGillDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Kirsten ClementDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Charles M QuickDepartment of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Eric U YeeDepartment of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
D Keith WilliamsDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Larry A WalkerNational Center for Natural Products Research, University of Mississippi, University, MS, USA.
Mahmoud A ElSohlyNational Center for Natural Products Research, University of Mississippi, University, MS, USA.
Bill J GurleyCenter for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Igor KoturbashDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Funding

The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PARKER, PEARMAN · 2015 to 2024
$21.1M
The Role of the Mitochondrion in the Metabolic Stress Response to Burn TraumaP20GM109096 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI SWINDLE, TAREN · 2016 to 2025
$20.7M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Systems Pharmacology and Toxicology Training ProgramT32GM106999 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2013 to 2022
$1.4M
Arkansas Center for Clinical Translational ResearchKL2TR000063 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$459k
NCATS NIH HHS KL2 TR000063NCATS NIH HHS UL1 TR000039NIGMS NIH HHS P20 GM109005NIGMS NIH HHS P20 GM109096NIGMS NIH HHS T32 GM106999
6 · The paper itself

Abstract

Cannabidiol (CBD) is a major phytocannabinoid from

Indexed as

CannabidiolCannabisChemical and Drug Induced Liver InjuryLab-On-A-Chip DevicesLiverPlant ExtractsAnimalsDose-Response Relationship, DrugHepatocytesHumansMaleMiceMice, Inbred C57BLCannabidiolPlant ExtractsCannabidiolhepatotoxicityliver-on-chipmicrophysiological systemstranslational toxicology

Identifiers

PMID39155655
PMCPMC11836190

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.