In one paragraphArticle in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
W James DeardorffDivision of Geriatrics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-7947-3008 Bocheng JingDivision of Geriatrics, University of California, San Francisco, San Francisco, California, USA.
Matthew E GrowdonDivision of Geriatrics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-5997-4406 Leah J BlankDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-8719-6752 Tasce BongiovanniDepartment of Surgery, University of California, San Francisco, San Francisco, California, USA.
Kristine YaffeSan Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
W John BoscardinDivision of Geriatrics, University of California, San Francisco, San Francisco, California, USA.
Kenneth S BoockvarDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama, Birmingham, Alabama, USA.ORCID 0000-0003-1165-5558 Michael A SteinmanDivision of Geriatrics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-9564-9480 Funding
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9MInstitutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7MUnnecessary and Harmful Medication Use in Older Adults with DementiaP01AG066605 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MELISSA Diane ALDRIDGE · 2020 to 2026
$17.7MRESEARCH TRAINING IN GERIATRIC MEDICINET32AG000212 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 1991 to 2026
$7.7MPopulation Based Research for Alzheimer's Innovation (POP BRAIN)R35AG071916 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2021 to 2024
$3.8MUCSF Learning Health System K12 Career Development ProgramK12HS026383 · AHRQ · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GONZALES, RALPH, SARKAR, URMIMALA · 2018 to 2022
$3.6MPrescribing cascades in older adults with and without dementiaK24AG049057 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEINMAN, MICHAEL A. · 2015 to 2025
$1.8MOptimizing medication use and support among people with dementia who live aloneK76AG088411 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew Evan Growdon · 2024 to 2026
$804kSeizure, cognitive change and dementia: Understanding the use and safety of anti-seizure medicationsK23AG080163 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Leah Blank · 2023 to 2026
$664kProlonged Use of Pain Medication Past the Postoperative Period in Older AdultsK23AG073523 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BONGIOVANNI, TASCE RIIKA SIMON · 2022 to 2025
$653kMedication risks and challenges among people with dementia who live aloneR03AG078804 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROWDON, MATTHEW EVAN · 2022 to 2023
$323kA comprehensive prognostic model for older adults discharged to skilled nursing facilities.R03AG082859 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEARDORFF, WILLIAM JAMES · 2023 to 2024
$323kAHRQ HHS K12 HS026383National Center for Advancing Translational Sciences of the National Institutes of Health KL2TR001870National Institutes of Health/Agency for Healthcare Research and Quality K12HS026383NCATS NIH HHS KL2 TR001870NIA NIH HHS K23 AG073523NIA NIH HHS K23 AG080163NIA NIH HHS K24 AG049057NIA NIH HHS K76 AG088411NIA NIH HHS L30 AG074160NIA NIH HHS P01 AG066605NIA NIH HHS P30 AG044281NIA NIH HHS R03 AG078804NIA NIH HHS R03 AG082859NIA NIH HHS R35 AG071916NIA NIH HHS T32 AG000212NIA NIH HHS T32AG000212Robert Wood Johnson Foundation P055312Veterans Affairs Patient Safety Centers of Inquiry
6 · The paper itselfAbstract
backgroundHospitalizations are frequently disruptive for persons with dementia (PWD) in part due to the use of potentially problematic medications for complications such as delirium, pain, and insomnia. We sought to determine the impact of hospitalizations on problematic medication prescribing in the months following hospitalization.
methodsWe included community-dwelling PWD in the Health and Retirement Study aged ≥66 with a hospitalization from 2008 to 2018. We characterized problematic medications as medications that negatively affect cognition (strongly anticholinergics/sedative-hypnotics), medications from the 2019 Beers criteria, and medications from STOPP-V2. To capture durable changes, we compared problematic medications 4 weeks prehospitalization (baseline) to 4 months posthospitalization period. We used a generalized linear mixed model with Poisson distribution adjusting for age, sex, comorbidity count, prehospital chronic medications, and timepoint.
resultsAmong 1 475 PWD, 504 had a qualifying hospitalization (median age 84 (IQR = 79-90), 66% female, 17% Black). There was a small increase in problematic medications from the baseline to posthospitalization timepoint that did not reach statistical significance (adjusted mean 1.28 vs 1.40, difference 0.12 (95% CI -0.03, 0.26), p = .12). Results were consistent across medication domains and certain subgroups. In one prespecified subgroup, individuals on <5 prehospital chronic medications showed a greater increase in posthospital problematic medications compared with those on ≥5 medications (p = .04 for interaction, mean increase from baseline to posthospitalization of 0.25 for those with <5 medications (95% CI 0.05, 0.44) vs. 0.06 (95% CI -0.12, 0.25) for those with ≥5 medications).
conclusionsHospitalizations had a small, nonstatistically significant effect on longer-term problematic medication use among PWD.
Indexed as
DementiaHospitalizationIndependent LivingAgedAged, 80 and overFemaleHumansInappropriate PrescribingMaleMedication overusePolypharmacyPotentially inappropriate medication
Identifiers
PMID39155601
PMCPMC11419320
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