Evidence map›Paper›PMID 39155435›Full record

ReviewMolecular and cellular biology2024

Functional Roles of H3K4 Methylation in Transcriptional Regulation.

Haoming Yu, Bluma J Lesch

Abstract readReview
In one paragraph

Review in Molecular and cellular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Set1 promotes Notch-induced transcriptional activation.Cellular and molecular life sciences : CMLS · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Haoming YuDepartment of Genetics, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-6231-7183
Bluma J LeschDepartment of Genetics, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-6689-0240

Funding

Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung CancerP50CA196530 · NCI · YALE UNIVERSITY · PI Harriet M. Kluger · 2015 to 2026
$31.1M
Germline Utx mutation as a model for transgenerational epigenetic inheritanceR01HD098128 · NICHD · YALE UNIVERSITY · PI LESCH, BLUMA J · 2020 to 2024
$2.0M
Defining the role of DOT1L in chromocenter stabilization pre- and post-fertilizationR21HD110843 · NICHD · YALE UNIVERSITY · PI LESCH, BLUMA J · 2023 to 2023
$461k
Defining signatures of epigenetic sensitization to lung cancer in a mouse modelR21CA288677 · NCI · YALE UNIVERSITY · PI LESCH, BLUMA J · 2024 to 2025
$430k
NCI NIH HHS P50 CA196530NCI NIH HHS R21 CA288677NICHD NIH HHS R01 HD098128NICHD NIH HHS R21 HD110843
6 · The paper itself

Abstract

Histone 3 lysine 4 methylation (H3K4me) is a highly evolutionary conserved chromatin modification associated with active transcription, and its three methylation states-mono, di, and trimethylation-mark distinct regulatory elements. However, whether H3K4me plays functional roles in transcriptional regulation or is merely a by-product of histone methyltransferases recruited to actively transcribed loci is still under debate. Here, we outline the studies that have addressed this question in yeast,

Indexed as

HistonesTranscription, GeneticAnimalsCell DifferentiationChromatinEpigenesis, GeneticGene Expression RegulationHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHumansMethylationChromatinhistone H3 trimethyl Lys4Histone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesChromatindifferentiationhistonemethylationtranscription

Identifiers

PMID39155435
PMCPMC11529435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.