Evidence map›Paper›PMID 39155339›Full record

ArticleEJNMMI reports2024

PSMA-PET/CT response after metastasis-directed radiotherapy of bone oligometastases in prostate cancer.

Gabriel T Sheikh, Christian Trapp, Nina-Sophie Schmidt-Hegemann, Alexander Buchner, Christian G Stief, Marcus Unterrainer, Wolfgang G Kunz, Clemens C Cyran, Freba Grawe, Astrid Delker and 7 more

Abstract read
In one paragraph

Article in EJNMMI reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gabriel T SheikhDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany. Gabriel.Sheikh@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-7026-9203
Christian TrappDepartment of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.
Nina-Sophie Schmidt-HegemannDepartment of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.
Alexander BuchnerDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Christian G StiefDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Marcus UnterrainerDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Wolfgang G KunzDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Clemens C CyranDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Freba GraweGerman Cancer Research Center (DKFZ), Hector Cancer Institute at the University Medical Center Mannheim, Heidelberg, Germany.
Astrid DelkerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Mathias J ZacherlDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Adrien HolzgreveDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Lena M UnterrainerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Claus BelkaDepartment of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.
Minglun Li *Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.
Paul Rogowski *Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBone metastases are very common in advanced prostate cancer and can sensitively be detected utilizing PSMA-PET/CT. Therefore, our goal was to evaluate the suitability of PSMA-PET/CT-guided metastasis-directed external beam radiotherapy (MDT) as treatment option for patients with biochemical recurrence and oligometastatic bone lesions. MATERIALS &

methodsWe retrospectively examined 32 prostate cancer patients with biochemical recurrence and PSMA-positive oligometastatic disease limited to the bone (n = 1-3). A total of 49 bone lesions were treated with MDT. All patients received a post-radiotherapy PSMA-PET/CT-Scan. Changes in SUV

resultsMDT lead to a SUV

conclusionMDT is a very effective treatment modality for prostate cancer bone oligometastases and lesion response to MDT can be assessed using the (semi-)quantitative parameters SUV

Indexed as

Metastases directed therapy (MDT)Oligometastatic prostate cancer (OMPC)PET/CTProstate specific membrane antigen (PSMA)Response assessment

Identifiers

PMID39155339
PMCPMC11330950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.