ArticleJournal of cachexia, sarcopenia and muscle2024
Higher serum uric acid as a risk factor for frailty in older adults: A nationwide population-based study.
Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between gout, hyperuricemia, and Parkinson's disease: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- The relationship between the uric acid to prealbumin ratio and frailty, muscle strength, and malnutrition risk in older geriatric outpatients: a retrospective cross-sectional study.BMC geriatrics · 2026Article
- Differential associations of febuxostat and allopurinol with incident and worsening frailty risk in nephrology patients.International journal of medical sciences · 2026Article
- Relationship between berry intake and frailty in the elderly and the mediating role of six blood markers: based on Chinese and American studies.Frontiers in nutrition · 2026Article
- Low Serum 25-Hydroxyvitamin D as a Risk Factor for Frailty in Community-Dwelling Older Men: A Korean Nationwide Study.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- The role of serum uric acid in frailty among individuals with reduced renal function: a cross-sectional study base on CHARLS.Scientific reports · 2025Article
- The Influence of Uric Acid Concentration on the Daily Functioning of Patients at an Advanced Age, Based on the Results of Selected Point Scales Routinely Used for the Comprehensive Geriatric Assessment in Poland.Journal of clinical medicine · 2025Article
- Elevated Serum Gamma-Glutamyl Transferase as a Risk Factor for Frailty in Older Men: A Nationwide Population-Based Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association between frailty with kidney stones disease among adults aged 20 years and older population: a cross-sectional study of NHANES 2007-2020.European journal of medical research · 2025Article
- Blood-based biomarkers and neuroimaging for early detection of post-stroke cognitive impairment: current evidence and synergistic prospects.Frontiers in neurology · 2025Review
- Higher serum uric acid as a risk factor for frailty in older adults: A nationwide population-based study.Journal of cachexia, sarcopenia and muscle · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundUric acid (UA), the terminal breakdown product of purine metabolism, possesses contradictory roles, functioning both as an inflammatory mediator and as an antioxidant. Its clinical relevance, particularly in geriatric populations, remains a topic of ongoing debate. Aiming to elucidate whether circulating UA is detrimental or beneficial to human health, we investigate the association between serum UA concentrations and the frailty index-a comprehensive measure of biological aging in a nationally representative cohort of community-dwelling older adults.
methodsWe conducted a population-based, cross-sectional study utilizing data from the Korea National Health and Nutrition Examination Survey. The sample included 4268 participants aged 65 years and above. A deficit accumulation frailty index (FI) was constructed using 38 items that assess physical, cognitive, psychological, and social domains. Based on the FI, participants were categorized into non-frail (FI ≤ 0.15), pre-frail (0.15 < FI ≤ 0.25), or frail (FI > 0.25). Serum UA levels were quantified through a colorimetric enzymatic assay.
resultsAfter controlling for confounders such as age, sex, socioeconomic status (including income and education level), lifestyle factors (smoking status), and medical history (hypertension, diabetes, dyslipidemia, stroke, cardiovascular diseases), and body mass index, serum UA levels were observed to be significantly higher in frail participants compared with their non-frail counterparts (P < 0.001). Furthermore, serum UA concentrations demonstrated a positive correlation with the FI (P < 0.001), and the odds ratio for frailty per 1 mg/dL increase in serum UA was 1.22 (P < 0.001). Additionally, older adults in the highest quartile of UA levels exhibited a significantly higher FI and 1.66-fold increased odds of frailty compared with those in the lowest quartile (P = 0.011 and P = 0.005, respectively).
conclusionsThese findings suggest that elevated circulating UA levels may act as a pro-aging factor rather than an anti-aging one in older adults, highlighting its potential role in accelerating biological aging. The data further support the utility of serum UA as a potential blood-based biomarker for frailty in this demographic, contributing to the expanding evidence on its significance in geriatric health assessments.
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