Evidence map›Paper›PMID 39154854›Full record

ReviewMatrix biology : journal of the International Society for Matrix Biology2024

Collagen VIII in vascular diseases.

Qian Li, Yin Tintut, Linda L Demer, Roberto I Vazquez-Padron, Michelle P Bendeck, Jeffrey J Hsu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Matrix biology : journal of the International Society for Matrix Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Type VIII collagen: advances in matrix biology and translational promise.Frontiers in bioengineering and biotechnology · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Collagen VIII: a new guardian of endothelial cell identity in atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  7. Review
  8. Article
  9. COL8A1 regulates endothelial phenotype in inflammatory endothelial-to-mesenchymal transition.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  10. The Role ofCancers · 2025
    Review
  11. Article
  12. RNA 5-Methylcytosine Modification in Myocardial Fibrosis.Reviews in cardiovascular medicine · 2025
    Review
  13. Review
  14. Targeting collagen to optimize cancer immunotherapy.Experimental hematology & oncology · 2025
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qian LiDepartments of Physiology, Bioengineering University of California, Los Angeles, Los Angeles, California, USA.
Yin TintutDepartments of Physiology, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Departments of Medicine, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Departments of Orthopedic Surgery, Bioengineering University of California, Los Angeles, Los Angeles, California, USA.
Linda L DemerDepartments of Physiology, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Departments of Medicine, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Bioengineering University of California, Los Angeles, Los Angeles, California, USA.
Roberto I Vazquez-PadronDepartment of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA; Bruce W. Carter Veteran Affairs Medical Center, Miami, Florida, USA.
Michelle P BendeckDepartments of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada; Ted Rogers Heart Research Centre, University of Toronto, Toronto, Ontario, Canada.
Jeffrey J HsuDepartments of Physiology, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California, USA. Electronic address: jjhsu@mednet.ucla.edu.

Funding

Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcificationR01HL151391 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2021 to 2024
$2.2M
The Role of Vascular Calprotectin in Arteriovenous Fistula MaturationR01DK132888 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Roberto Irenardo Vazquez Padron · 2022 to 2026
$2.1M
Dual Role of Lysyl Oxidase in Arteriovenous Fistula FailureR01DK121227 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHIU, YAN-TING E., VAZQUEZ PADRON, ROBERTO IRENARDO · 2019 to 2023
$2.1M
Serotonin receptor contribution to inflammation-induced calcific aortic valve diseaseR01HL137647 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2019 to 2022
$1.6M
Integrin Activation to Prevent Early Arteriovenous Fistula Failure in End-stage Renal Disease PatientsR01DK136297 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI VINEET GUPTA, YAN-TING E. SHIU · 2024 to 2026
$1.5M
Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular CalcificationK08HL151961 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSU, JEFFREY JOHN · 2020 to 2024
$646k
The Multiple Roles of Lysyl Oxidase in Arteriovenous Fistula FailureI01BX004658 · VA · MIAMI VA HEALTH CARE SYSTEM · PI VAZQUEZ PADRON, ROBERTO IRENARDO · 2020 to 2023
–
BLRD VA I01 BX004658BLRD VA I01 BX006080BLRD VA IK6 BX006823NHLBI NIH HHS K08 HL151961NHLBI NIH HHS R01 HL137647NHLBI NIH HHS R01 HL151391NIDDK NIH HHS R01 DK121227NIDDK NIH HHS R01 DK132888NIDDK NIH HHS R01 DK136297
6 · The paper itself

Abstract

Collagens have dual functions in the extracellular matrix (ECM), acting as both structural components and signaling molecules in matricellular communication. Although collagen molecules share a common triple helix motif, the supramolecular organization helps classify them into nearly 30 different types of collagens. Collagen type VIII is a non-fibrillar, short-chain, network-forming collagen that is expressed throughout the vasculature. Collagen VIII expression is aberrant in cardiovascular, lung, and renal disease, as well as in several different types of cancer. It plays active roles in angiogenesis, vessel injury repair, maintenance of arterial compliance, atherosclerotic plaque formation and stability modulation, fibrosis, and ECM remodeling. This review presents an overview of the characteristics of collagen VIII in vascular-related disorders, from clinical significance to laboratory studies, with a major focus on highlighting the signaling properties of collagen VIII in the vascular ECM. The expression patterns of collagen VIII in human diseases and experimental animal models highlight the protein's important yet underexplored functions. A deeper understanding of its mechanisms and downstream signaling pathways may pave the way for translational and tissue engineering applications of collagen VIII.

Indexed as

Collagen Type VIIIExtracellular MatrixSignal TransductionVascular DiseasesAnimalsHumansCollagen Type VIIIAngiogenesisCOL8A1Collagen type VIIICollagen VIIIExtracellular matrixVascular diseaseVascular remodeling

Identifiers

PMID39154854
PMCPMC11473120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.