ArticleCNS neuroscience & therapeutics2024
Unveiling the interoception impairment in various major depressive disorder stages.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Shared neuroimaging and molecular profiles in type 2 diabetes mellitus and major depressive disorder: an integrative analysis of genetic, transcriptomic, and neuroimaging data.Translational psychiatry · 2025Pooled it
- Change starts with the body: Interoceptive appreciation mediates the effect of mindfulness training on behavior change - an effect moderated by depression severity.Psychiatry research · 2024Trial
- Interoception in obsessive-compulsive and major depressive disorders.Frontiers in psychology · 2026Article
- Reduced Trust in Bodily Sensations Predicts Suicidal Ideation in Hospitalized Patients With Major Depression: An Observational Study.Suicide & life-threatening behavior · 2025Observational
- Depression May Not Be Related to Impaired Interoceptive Sensibility: The Role of Alexithymia.Behavioral sciences (Basel, Switzerland) · 2025Article
- Real-time fMRI neurofeedback boosts heartbeat perception by modulating insula activation pattern during interoceptive attention.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Unveiling the interoception impairment in various major depressive disorder stages.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe intricate pathophysiological mechanisms of major depressive disorder (MDD) necessitate the development of comprehensive early indicators that reflect the complex interplay of emotional, physical, and cognitive factors. Despite its potential to fulfill these criteria, interoception remains underexplored in MDD. This study aimed to evaluate the potential of interoception in transforming MDD's clinical practices by examining interoception deficits across various MDD stages and analyzing their complex associations with the spectrum of depressive symptoms.
methodsThis study included 431 healthy individuals, 206 subclinical depression individuals, and 483 MDD patients. Depressive symptoms and interoception function were assessed using the PHQ-9 and MAIA-2, respectively.
resultsInteroception dysfunction occurred in the preclinical phase of MDD and further impaired in the clinical stage. Antidepressant therapies showed limited efficacy in improving interoception and might damage some dimensions. Interoceptive dimensions might predict depressive symptoms, primarily enhancing negative thinking patterns. The predictive model based on interoception was built with random split verification and demonstrated good discrimination and predictive performance in identifying MDD.
conclusionsEarly alterations in the preclinical stage, multivariate associations with depressive symptoms, and good discrimination and predictive performance highlight the importance of interoception in MDD management, pointing to a paradigm shift in diagnostic and therapeutic approaches.
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