Evidence map›Paper›PMID 39154325›Full record

ArticleIslets2024

Small RNA-Seq and real time rt-qPCR reveal islet miRNA released under stress conditions.

Bssam Aljani, Annett Lindner, Marc Weigelt, Min Zhao, Virag Sharma, Ezio Bonifacio, Peter Jones, Anne Eugster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Islets, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bssam AljaniFaculty of Medicine, Center for Regenerative Therapies Dresden, Dresden, Germany.
Annett LindnerFaculty of Medicine, Center for Regenerative Therapies Dresden, Dresden, Germany.
Marc WeigeltFaculty of Medicine, Center for Regenerative Therapies Dresden, Dresden, Germany.
Min ZhaoGerman Center for Environmental Health, Institute of Diabetes Research, Helmholtz Munich, Munich, Germany.
Virag SharmaFaculty of Medicine, Center for Regenerative Therapies Dresden, Dresden, Germany.
Ezio BonifacioFaculty of Medicine, Center for Regenerative Therapies Dresden, Dresden, Germany.
Peter JonesDepartment of Diabetes, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK.
Anne EugsterFaculty of Medicine, Center for Regenerative Therapies Dresden, Dresden, Germany.ORCID 0000-0001-8009-5959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replacement of beta cells through transplantation is a potential therapeutic approach for individuals with pancreas removal or poorly controllable type 1 diabetes. However, stress and death of beta cells pose significant challenges. Circulating miRNA has emerged as potential biomarkers reflecting early beta cell stress and death, allowing for timely intervention. The aim of this study was to identify miRNAs as potential biomarkers for beta cell health. Literature review combined with small RNA sequencing was employed to select islet-enriched miRNA. The release of those miRNA was assessed by RT-qPCR

Indexed as

Diabetes Mellitus, ExperimentalIslets of LangerhansMicroRNAsAnimalsDiabetes Mellitus, Type 1HumansInsulin-Secreting CellsMaleMiceMice, Inbred C57BLReal-Time Polymerase Chain ReactionRNA-SeqStress, PhysiologicalMicroRNAsBiomarkerislet beta cell stressmiRNAT1Dtransplantation

Identifiers

PMID39154325
PMCPMC11332650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.