Evidence map›Paper›PMID 39154179›Full record

ArticleJournal of neurodevelopmental disorders2024

Parent attitudes towards predictive testing for autism in the first year of life.

Aurora M Washington, Amanda H Mercer, Catherine A Burrows, Stephen R Dager, Jed T Elison, Annette M Estes, Rebecca Grzadzinski, Chimei Lee, Joseph Piven, John R Pruett and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aurora M WashingtonUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Amanda H MercerPortland State University, Portland, OR, USA.
Catherine A BurrowsUniversity of Minnesota, Minneapolis, MN, USA.
Stephen R DagerUniversity of Washington, Seattle, WA, USA.
Jed T ElisonUniversity of Minnesota, Minneapolis, MN, USA.
Annette M EstesUniversity of Washington, Seattle, WA, USA.
Rebecca GrzadzinskiUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Chimei LeeUniversity of Minnesota, Minneapolis, MN, USA.
Joseph PivenUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
John R PruettWashington University School of Medicine in St. Louis, St. Louis, MO, USA.
Mark D ShenUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Benjamin WilfondUniversity of Washington, Seattle, WA, USA.
Jason WolffUniversity of Minnesota, Minneapolis, MN, USA.
Lonnie ZwaigenbaumUniversity of Alberta, Edmonton, Alberta, Canada.
Katherine E MacDuffieUniversity of Washington, Seattle, WA, USA. kate.macduffie@seattlechildrens.org.

Funding

Neuroethics of Predictive MRI Testing: Parental Attitudes Towards Pre-Symptomatic Identification of Autism Spectrum DisorderF32MH118689 · NIMH · UNIVERSITY OF WASHINGTON · PI MACDUFFIE, KATE E. · 2018 to 2019
$130k
NIMH NIH HHS F32 MH118689NIMH NIH HHS F32MH118689
6 · The paper itself

Abstract

backgroundEmerging biomarker technologies (e.g., MRI, EEG, digital phenotyping, eye-tracking) have potential to move the identification of autism into the first year of life. We investigated the perspectives of parents about the anticipated utility and impact of predicting later autism diagnosis from a biomarker-based test in infancy.

methodsParents of infants were interviewed to ascertain receptiveness and perspectives on early (6-12 months) prediction of autism using emerging biomarker technologies. One group had experience parenting an older autistic child (n=30), and the other had no prior autism parenting experience (n=25). Parent responses were analyzed using inductive qualitative coding methods.

resultsAlmost all parents in both groups were interested in predictive testing for autism, with some stating they would seek testing only if concerned about their infant's development. The primary anticipated advantage of testing was to enable access to earlier intervention. Parents also described the anticipated emotions they would feel in response to test results, actions they might take upon learning their infant was likely to develop autism, attitudes towards predicting a child's future support needs, and the potential impacts of inaccurate prediction.

conclusionIn qualitative interviews, parents of infants with and without prior autism experience shared their anticipated motivations and concerns about predictive testing for autism in the first year of life. The primary reported motivators for testing-to have more time to prepare and intervene early-could be constrained by familial resources and service availability. Implications for ethical communication of results, equitable early intervention, and future research are discussed.

Indexed as

Autistic DisorderParentsAdultAutism Spectrum DisorderBiomarkersFemaleHumansInfantMaleQualitative ResearchBiomarkersAutismBioethicsBiomarkersPredictionStakeholder engagement

Identifiers

PMID39154179
PMCPMC11330042

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.