ArticleLipids in health and disease2024
Non-linear association of triglyceride-glucose index with cardiovascular and all-cause mortality in T2DM patients with diabetic kidney disease: NHANES 2001-2018 retrospective cohort study.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- The mediating effect role of methylmalonic acid on the association between oxidative balance score and diabetic kidney disease: a cross-sectional study from NHANES 2011-2014.Renal failure · 2026Article
- Prognostic role of triglyceride-glucose index and triglyceride-glucose body mass index in patients undergoing coronary artery bypass grafting: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- Body roundness index mediates the association between high-density lipoprotein cholesterol and diabetic retinopathy: a population-based cross-sectional study.BMC endocrine disorders · 2026Article
- The Association Between Triglyceride-Glucose Index and Mortality Risk in Cardiovascular Disease Patients: A Meta-Analysis.Journal of clinical medicine research · 2026Article
- Dual electrochemical sensor based on graphene aerogel for quantification of ascorbic acid in pharmaceutical samples and uric acid in urine.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Predicting 1-Year Renal Outcomes in Patients with Diabetic Kidney Disease in CKD Stages 3 to 4: A Multimodal Machine Learning Approach Fusing Clinical Composites and Pathology Images.Research (Washington, D.C.) · 2026Article
- Association of triglyceride glucose index with cardiovascular autonomic neuropathy in type 2 diabetes mellitus.Frontiers in cardiovascular medicine · 2026Article
- Development and External Validation of a Clinically Applicable Model for Identifying Diabetic Kidney Disease in Population-Based and Clinical Cohorts.International journal of general medicine · 2026Article
- Development and Validation of an Integrated Metabolism-Obesity Index for Screening Renal Impairment in Patients With Newly Diagnosed Type 2 Diabetes Mellitus.Journal of diabetes research · 2026Article
- When Obesity Hits the Kidneys: Sex-Specific Effects of Visceral Adiposity Indices on Diabetic Kidney Disease Risk.Journal of nutrition and metabolism · 2026Article
- Association of the triglyceride-glucose index with all-cause and cause-specific mortality in patients with comorbid hypertension and diabetes: A population-based cohort study.American heart journal plus : cardiology research and practice · 2025Article
- Association of atherogenic index of plasma with cardiovascular disease mortality in patients with type 2 diabetes mellitus and diabetic kidney disease: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Relationship between the triglyceride glucose index and time in range: A cross-sectional study based on patients with type 2 diabetes mellitus.The Journal of international medical research · 2025Article
- Weight-adjusted waist index and mortality in diabetic retinopathy: a NHANES 1999-2018 cohort study.Diabetology & metabolic syndrome · 2025Article
- Use of blood glucose level for predicting the degree of coronary artery disease and cardiovascular adverse events in diabetic patients with acute coronary syndrome.American journal of translational research · 2025Article
- Association of Chronotype with Hypertension and Metabolic Parameters in Middle-Aged and Older Adults: A Cross-Sectional Study.Nature and science of sleep · 2025Article
- Exploring the nonlinear relationship between serum uric acid to high-density lipoprotein cholesterol ratio and obesity in older adults: a cross-sectional study.Frontiers in public health · 2025Article
- Sex- and Age-Specific Associations of Triglyceride-Glucose Index with Impaired Renal Function: A Cross-Sectional Study.International journal of general medicine · 2025Article
- Inflammatory storm and metabolic disorders: unraveling heterogeneity in mortality risk for comorbid diabetes mellitus and heart failure via the C-reactive protein-triglyceride-glucose index.Frontiers in endocrinology · 2025Article
- Independent and combined associations of high-density lipoprotein cholesterol-modified triglyceride-glucose index with all-cause and cardiovascular mortality in patients with acute decompensated heart failure.Frontiers in endocrinology · 2025Article
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7 authors.
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Abstract
backgroundThe triglyceride glucose (TyG) index is a cutting-edge and highly effective marker of insulin resistance, a crucial factor in the development and exacerbation of diabetic kidney disease (DKD). To date, there has been limited research on how the triglyceride-glucose (TyG) index affects the outlook for patients suffering from DKD.
methodsIn this multicenter retrospective cohort study, the analysis recruited 2,203 DKD patients from the National Health and Nutrition Examination Survey (NHANES) dataset, which covers the US from 2001 to 2018. The research applied a Cox proportional hazards model with multiple variables to investigate the association of the TyG index with mortality outcomes. Restricted cubic splines (RCS) and methods for analyzing threshold effects were employed to identify possible non-linear relationships.
resultsOver nearly 19 years of follow-up, this study captured data on 753 all-cause and 231 cardiovascular disease-specific fatalities. Sophisticated statistical methods, including RCS and smoothing curve adjustments via penalized splines, helped identify distinctive patterns: The baseline TyG index was observed to have a U-shaped pattern related to overall mortality and an L-shape with cardiovascular diseases(CVD) mortality among individuals with DKD. Notably, TyG index below 9.15 for overall mortality and 9.27 for CVD mortality were linked to reduced death rates (HR = 0.65, 95% CI = 0.52-0.82 for all-cause; HR = 0.58, 95% CI = 0.43-0.83 for CVD). On the other hand, TyG index exceeding these benchmarks (greater than 9.15 for all-cause and 9.27 for CVD) correlated with increased all-cause mortality risks (HR = 1.21, 95% CI = 1.02-1.43) and showed a non-significant change in CVD mortality risks (HR = 1.07, 95% CI = 0.83-1.38).
conclusionsThis study emphasizes the non-linear linkage involving the TyG index and death rates due to CVD and other factors in patients with DKD, demonstrating its effectiveness in estimating potential adverse events within this demographic.
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