Evidence map›Paper›PMID 39154143›Full record

ArticlePediatric research2025

Comparison of standard and global hemostasis assays in cord and peripheral blood of newborns.

Belinda V Arutunyan, Ekaterina M Koltsova, Margarita A Shpilyuk, Elena N Lipets, Leila A Timofeeva, Anna L Karavaeva, Ekaterina N Balashova, Liubov V Krechetova, Fazoil I Ataullakhanov, Viktor V Zubkov and 4 more

Abstract readComparative Study
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In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Belinda V ArutunyanNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Ekaterina M KoltsovaCenter for Theoretical Problems of Physicochemical Pharmacology RAS, Moscow, 109029, Russia.
Margarita A ShpilyukNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Elena N LipetsCenter for Theoretical Problems of Physicochemical Pharmacology RAS, Moscow, 109029, Russia.
Leila A TimofeevaNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Anna L KaravaevaNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Ekaterina N BalashovaNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Liubov V KrechetovaNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Fazoil I AtaullakhanovCenter for Theoretical Problems of Physicochemical Pharmacology RAS, Moscow, 109029, Russia.
Viktor V ZubkovNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Dmitry N DegtyarevNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Gennady T SukhikhNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Nana K TetruashviliNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I., Moscow, 117997, Russia.
Anna N BalandinaCenter for Theoretical Problems of Physicochemical Pharmacology RAS, Moscow, 109029, Russia. a_balandina@inbox.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUmbilical cord blood is used for the testing of various parameters in newborns. However, data on its applicability for hemostasis assays is insufficient.

objectiveTo evaluate whether umbilical cord blood can be used for standard tests, thromboelastometry and thrombodynamics for preterm and term newborns.

methods187 newborns were included in the study. Blood was taken from the umbilical cord and by venipuncture of the newborn. Clotting times, fibrinogen, D-dimer, thromboelastometry and thrombodynamics were measured.

resultsClotting times and fibrinogen indicated a hypocoagulable shift, while thromboelastometry and thrombodynamics showed a hypercoagulable shift in hemostasis in umbilical cord blood compared to newborn blood. D-dimer indicated an enhanced process of thrombus lysis in newborn blood compared to cord blood. Collecting blood into a tube with the addition of a contact pathway inhibitor did not significantly change the global assay parameters in either umbilical cord blood or newborn blood. In the thrombodynamics assay, spontaneous clotting was detected but suppressed by the addition of a tissue factor inhibitor.

conclusionsHemostasis in cord and newborn blood differs for both global and standard tests. Hypercoagulability in newborns registered with the global assay thrombodynamics is associated with the presence of tissue factor in the blood. IMPACT STATEMENT: 1. We found a hypercoagulation shift in newborns compared with the adult references, possibly due to the presence of tissue factor in blood. 2. Blood coagulation is enhanced in cord blood compared with blood sampled from the vein of a newborn according to thromboelastometry and thrombodynamics assays. 3. Clotting times and fibrinogen concentrations in cord blood differ from these parameters in newborn blood. 4. Studying of the (patho)physiological features of hemostasis in newborns should consider differences in cord blood and vein sampled blood.

Indexed as

Fetal BloodHemostasisBlood CoagulationBlood Coagulation TestsFemaleFibrin Fibrinogen Degradation ProductsFibrinogenHumansInfant, NewbornInfant, PrematureMaleThrombelastographyFibrin Fibrinogen Degradation Productsfibrin fragment DFibrinogen

Identifiers

PMID39154143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.