Evidence map›Paper›PMID 39154093›Full record

ArticleScientific reports2024

TEMPRO: nanobody melting temperature estimation model using protein embeddings.

Jerome Anthony E Alvarez, Scott N Dean

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jerome Anthony E AlvarezNaval Research Laboratory, Center for Bio/Molecular Science and Engineering, Washington, DC, USA.
Scott N DeanNaval Research Laboratory, Center for Bio/Molecular Science and Engineering, Washington, DC, USA. Scott.N.Dean.civ@us.navy.mil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-domain antibodies (sdAbs) or nanobodies have received widespread attention due to their small size (~ 15 kDa) and diverse applications in bio-derived therapeutics. As many modern biotechnology breakthroughs are applied to antibody engineering and design, nanobody thermostability or melting temperature (T

Indexed as

Single-Domain AntibodiesComputational BiologyModels, MolecularProtein StabilityTransition TemperatureSingle-Domain AntibodiesAntibodiesMachine learningNanobodiesNeural networksProteinsSingle-domain antibodiesThermostability

Identifiers

PMID39154093
PMCPMC11330463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.