Evidence map›Paper›PMID 39154015›Full record

ReviewBiological procedures online2024

Photodynamic Therapy: A Novel Approach for Head and Neck Cancer Treatment with Focusing on Oral Cavity.

Kimia Sadat Kazemi, Parisa Kazemi, Hassan Mivehchi, Kamyar Nasiri, Seyed Saman Eshagh Hoseini, Seyedeh Tabasom Nejati, Parnian Pour Bahrami, Shayan Golestani, Mohsen Nabi Afjadi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological procedures online, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kimia Sadat KazemiFaculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Parisa KazemiFaculty of Dentistry, Ilam University of Medical Sciences, Ilam, Iran.
Hassan MivehchiFaculty of Dentistry, University of Debrecen, Debrecen, Hungary.
Kamyar NasiriFaculty of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran.
Seyed Saman Eshagh HoseiniFaculty of Dentistry, Qom University of Medical Sciences, Qom, Iran.
Seyedeh Tabasom NejatiSchool of Dentistry, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Parnian Pour BahramiFaculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Shayan GolestaniDepartment of Oral and Maxillofacial Surgery, Dental School, Islamic Azad University, Isfahan, Iran. Shayan.golestani@gmail.com.
Mohsen Nabi AfjadiDepartment of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. mohsennabi66@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cancers, specifically oral squamous cell carcinoma (OSCC), pose a significant global health challenge, with high incidence and mortality rates. Conventional treatments such as surgery, radiotherapy, and chemotherapy have limited effectiveness and can result in adverse reactions. However, as an alternative, photodynamic therapy (PDT) has emerged as a promising option for treating oral cancers. PDT involves using photosensitizing agents in conjunction with specific light to target and destroy cancer cells selectively. The photosensitizers accumulate in the cancer cells and generate reactive oxygen species (ROS) upon exposure to the activating light, leading to cellular damage and ultimately cell death. PDT offers several advantages, including its non-invasive nature, absence of known long-term side effects when administered correctly, and cost-effectiveness. It can be employed as a primary treatment for early-stage oral cancers or in combination with other therapies for more advanced cases. Nonetheless, it is important to note that PDT is most effective for superficial or localized cancers and may not be suitable for larger or deeply infiltrating tumors. Light sensitivity and temporary side effects may occur but can be managed with appropriate care. Ongoing research endeavors aim to expand the applications of PDT and develop novel photosensitizers to further enhance its efficacy in oral cancer treatment. This review aims to evaluate the effectiveness of PDT in treating oral cancers by analyzing a combination of preclinical and clinical studies.

Indexed as

Oral cancerOral squamous cell carcinomaPhotodynamic therapyPhotosensitizers

Identifiers

PMID39154015
PMCPMC11330087

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.