ArticleNature communications2024
Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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Who cites it
12 citing papers in PubMed.
- Harnessing intermediate-scale bioreactors for next-generation macrophage production and application.Nature protocols · 2026Review
- Endothelial progenitor cells are associated with improved vascular repair in experimental aortic dissection.Scientific reports · 2026Article
- Comparative analysis of the cellular landscape in mammalian striatum.Nature communications · 2026Article
- Blood vessel-resident macrophages safeguard blood and vessel integrity in zebrafish.Nature immunology · 2026Article
- Bmpr2 Drives Aberrant Activation and Injury of Glomerular Endothelial Cells in Lupus Nephritis.Journal of the American Society of Nephrology : JASN · 2026Article
- Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.Zoological letters · 2026Article
- The role of macrophages in aortic physiology and pathophysiology.Frontiers in immunology · 2026Review
- Stem Cell and Synthetic Embryo Models: Advances, Applications, and Ethical Considerations.Stem cell reviews and reports · 2025Review
- [Application progress of single-cell RNA sequencing technology in breast development and related diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Macrophage Containing Cardiac Organoids for Studying Inflammatory Programmes Driving Cardiovascular Disease.Current cardiology reports · 2025Review
- Unraveling hematopoietic stem cell ontogeny through single-cell multi-omics approaches.Frontiers in cell and developmental biology · 2025Review
- Trophic and temporal dynamics of macrophage biology in human inner ear organogenesis.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
27 authors.
Anna E Williamson *Vascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Sanuri Liyanage *Vascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Mohammadhossein HassanshahiVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Malathi S I DonaCardiac Cellular Systems Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.ORCID 0000-0002-0337-4417
Deborah Toledo-FloresVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Dang X A TranVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Catherine DimasiVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Nisha SchwarzVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Sanuja FernandoVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Thalia SalagarasVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Aaron LongVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Jan KazenwadelCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.ORCID 0000-0001-6216-3444
Natasha L HarveyAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0001-9839-8966
Grant R DrummondDepartment of Microbiology, Anatomy, Physiology and Pharmacology and Centre for Cardiovascular Biology and Disease Research, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia.
Antony VinhDepartment of Microbiology, Anatomy, Physiology and Pharmacology and Centre for Cardiovascular Biology and Disease Research, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia.ORCID 0000-0001-8367-6134
Vashe ChandrakanthanAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-4314-5029
Ashish MisraFaculty of Medicine and Health, University of Sydney and Heart Research Institute, Newtown, NSW, Australia.
Zoltan NeufeldSchool of Mathematics and Physics, The University of Queensland, Brisbane, QLD, Australia.
Joanne T M TanVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.ORCID 0000-0003-1875-4882
Luciano MartelottoAdelaide Centre for Epigenetics and the South Australian Immunogenomics Cancer Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-9625-1183
Jose M PoloAdelaide Centre for Epigenetics and the South Australian Immunogenomics Cancer Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-2531-778X
Claudine S BonderCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.ORCID 0000-0001-9875-967X
Alexander R PintoCardiac Cellular Systems Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.ORCID 0000-0001-6421-4970
Shiwani SharmaVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Stephen J NichollsMonash Cardiovascular Research Centre, Monash University, Melbourne, VIC, Australia.
Christina A BursillVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Peter J PsaltisVascular Research Centre, Heart and Vascular Program, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia. peter.psaltis@sahmri.com.ORCID 0000-0003-0222-5468
Funding
Counterpulsation Device with Integrated EKG System for Chronic Partial CirculatorR44HL102981 · NHLBI · SCR, INC. · PI SPENCE, PAUL A · 2012 to 2013
$1.6MEndothelial SK3 Channel Modulation of EDHF is Estrogen RegulatedR00HL102056 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LIN, MIKE T · 2012 to 2014
$686kCounterpulsation Device with Integrated ECG SensingR43HL102981 · NHLBI · SCR, INC. · PI DOWLING, ROBERT D. · 2010 to 2010
$239kEndothelial SK3 Channel Modulation of EDHF is Estrogen RegulatedK99HL102056 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LIN, MIKE T · 2010 to 2011
$194kDepartment of Health | National Health and Medical Research Council (NHMRC) CDF 1161506Department of Health | National Health and Medical Research Council (NHMRC) IG 2001541Department of Health | National Health and Medical Research Council (NHMRC) PG 1086796Department of Health | National Health and Medical Research Council (NHMRC) PRF 1111630National Heart Foundation of Australia (Heart Foundation) 102056National Heart Foundation of Australia (Heart Foundation) 106656National Heart Foundation of Australia (Heart Foundation) VG 102981Wellcome Trust 100412
Abstract
Converging evidence indicates that extra-embryonic yolk sac is the source of both macrophages and endothelial cells in adult mouse tissues. Prevailing views are that these embryonically derived cells are maintained after birth by proliferative self-renewal in their differentiated states. Here we identify clonogenic endothelial-macrophage (EndoMac) progenitor cells in the adventitia of embryonic and postnatal mouse aorta, that are independent of Flt3-mediated bone marrow hematopoiesis and derive from an early embryonic CX
Indexed as
AortaMacrophagesAngiotensin IIAnimalsCell DifferentiationCell ProliferationCX3C Chemokine Receptor 1Endothelial CellsFemalefms-Like Tyrosine Kinase 3HematopoiesisMaleMiceMice, Inbred C57BLNeovascularization, PhysiologicReceptors, ChemokineAngiotensin IICsf1r protein, mouseCX3C Chemokine Receptor 1Cx3cr1 protein, mouseFlt3 protein, mousefms-Like Tyrosine Kinase 3Receptors, ChemokineReceptors, Granulocyte-Macrophage Colony-Stimulating Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.