Evidence map›Paper›PMID 39153992›Full record

ArticleBMC public health2024

Age at separation, residential mobility, and depressive symptoms among twins in late adolescence and young adulthood: a FinnTwin12 cohort study.

Zhiyang Wang, Alyce M Whipp, Marja Heinonen-Guzejev, Jaakko Kaprio

Abstract readTwin Study
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zhiyang WangInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, PL 20 (Tukholmankatu 8), Helsinki, FI-00014, Finland.
Alyce M WhippInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, PL 20 (Tukholmankatu 8), Helsinki, FI-00014, Finland.
Marja Heinonen-GuzejevInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, PL 20 (Tukholmankatu 8), Helsinki, FI-00014, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, PL 20 (Tukholmankatu 8), Helsinki, FI-00014, Finland. jaakko.kaprio@helsinki.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeparating with close siblings and leaving the parental home at an early age represents a major life event for an adolescent (reflected by age at separation in a twin pair) and may predispose them to poor mental health. This study aims to examine the association of age at separation and residential mobility on depressive symptoms in late adolescence and young adulthood and to explore possible underlying genetic effects.

methodsResidential mobility consisted of the number and total distance of moves before age 17. Based on 3071 twins from the FinnTwin12 cohort, we used linear regression to assess the association of age at separation and residential mobility with General Behavior Inventory (GBI) scores at age 17 and in young adulthood. A higher GBI score indicated more depressive symptoms occurred. Then, the mixed model for repeated measures (MMRM) was used to visualize the scores' trajectory and test the associations, controlling for "baseline" state. Twin analyses with a bivariate cross-lagged path model were performed between the difference in GBI scores, between cotwins, and separation status for the potential genetic influence.

resultsCompared to twins separated before age 17, twins who separated later had significantly lower GBI scores at age 17 and in young adulthood. In MMRM, separation at a later age and a higher number of moves were associated with a higher GBI score in young adulthood. A small genetic effect was detected wherein GBI within-pair differences at age 17 were associated with separation status before age 22 (coefficient: 0.01).

conclusionThe study provides valid evidence about the influence of siblings and family on depressive symptoms in later adolescence and young adulthood while finding some evidence for a reverse direction effect. This suggests more caution in the interpretation of results. A strong association between residential mobility and depressive symptoms was affirmed, although further detailed research is needed.

Indexed as

DepressionAdolescentAge FactorsCohort StudiesFemaleFinlandHumansMalePopulation DynamicsTwinsYoung AdultAdolescentDepressive symptomResidential mobilityTwins

Identifiers

PMID39153992
PMCPMC11330072

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