Evidence map›Paper›PMID 39153481›Full record

ArticleCurrent biology : CB2024

The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis.

Bageshri Naimish Nanavati, Ivar Noordstra, Angela K O Lwin, John W Brooks, James Rae, Robert G Parton, Suzie Verma, Kinga Duszyc, Kathleen J Green, Alpha S Yap

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bageshri Naimish NanavatiCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Ivar NoordstraCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Angela K O LwinCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
John W BrooksCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
James RaeCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Robert G PartonCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia; Centre for Microscopy and Microanalysis, The University of Queensland, St. Lucia, QLD 4072, Australia.
Suzie VermaCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Kinga DuszycCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Kathleen J GreenDepartments of Pathology and Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 06011, USA.
Alpha S YapCentre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: a.yap@uq.edu.au.

Funding

MOLECULAR GENETICS OF PEMPHIGUS FOLIACEUS ANTIGENR01AR041836 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1993 to 2026
$11.8M
DESMOPLAKIN FUNCTION IN EPIDERMISR01AR043380 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1996 to 2026
$7.0M
Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and MelanomaR01CA228196 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 2019 to 2026
$3.7M
NCI NIH HHS R01 CA228196NIAMS NIH HHS R01 AR041836NIAMS NIH HHS R01 AR043380
6 · The paper itself

Abstract

Epithelial homeostasis can be critically influenced by how cells respond to mechanical forces, both local changes in force balance between cells and altered tissue-level forces.

Indexed as

Adherens JunctionsDesmosomesHomeostasisIntermediate FilamentsMechanotransduction, CellularAnimalsCadherinsDesmoplakinsDogsEpithelial CellsHumansMadin Darby Canine Kidney CellsrhoA GTP-Binding ProteinCadherinsDesmoplakinsrhoA GTP-Binding Proteindesmoplakinepitheliaintermediate filamentsmechanotransductionRhoA signaling

Identifiers

PMID39153481
PMCPMC11387132

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.