ArticleCell metabolism2024
Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.
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Article in Cell metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- Modulation of innate and adaptive immunity by pH-responsive nanozyme-like nanoparticles with high mobility for rheumatoid arthritis alleviation.Bioactive materials · 2026Article
- Inhibition of Calcium-Sensing Receptor Suppresses Malignant Behaviours of Human Hepatocellular Carcinoma.Journal of cellular and molecular medicine · 2026Article
- CBX4 stabilizes NEUROD1 through SUMO-ubiquitin crosstalk to delay β-cell senescence.Nature communications · 2026Article
- Mitochondrial NCLX couples glucagon- and PDE2A-Dependent signals to regulate hepatic lipid metabolism.Molecular metabolism · 2026Article
- Three-dimensional interactive network: Mitochondrial-metabolic-calcium homeostasis driving Alzheimer's disease.Genes & diseases · 2026Review
- The expanding landscape of the glucagon signaling network: mechanisms and outcomes.Endocrinology · 2026Review
- TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis.Molecular metabolism · 2026Article
- Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione-Mediated Stemness Maintenance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gut Microbiota-Derived Propionic Acid Mediates ApoA-I-Induced Amelioration of MASLD via Activation of GPR43-CaInternational journal of molecular sciences · 2026Article
- Targeting mitochondrial dysfunction to intervene in liver cancer.Cancer biology & medicine · 2025Review
- Hepatic ferredoxin reductase modulates mitochondrial function and iron homeostasis in metabolic dysfunction-associated steatotic liver disease.Research square · 2025Article
- Alnustone Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β-Oxidation via Targeting Calmodulin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Feedback Loops Shape Oxidative and Immune Interactions in Hepatic Ischemia-Reperfusion Injury.Antioxidants (Basel, Switzerland) · 2025Review
- NHE7 drives endometrial cancer progression by delaying senescence through cAMP/CREB/GRIN2B axis-mediated Ca²⁺ influx.Communications biology · 2025Article
- Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice.Mechanisms of ageing and development · 2025Article
- Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice.Cell & bioscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Traci E LaMoiaDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
Brandon T HubbardDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
Mateus T GuerraDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Ali NasiriDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Ikki SakumaDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Mario KahnDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Dongyan ZhangDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Russell P GoodmanMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Michael H NathansonDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
Yasemin SancakDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Mark PerelisIonis Pharmaceuticals, Carlsbad, CA 92010, USA.
Vamsi K MoothaMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Gerald I ShulmanDepartments of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: gerald.shulman@yale.edu.
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI Mario Strazzabosco · 1986 to 2026
$31.1MMedical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5MYale Mouse Metabolic Phenotyping CenterU24DK059635 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2001 to 2015
$8.9MTraining Program in Investigative HepatologyT32DK007356 · NIDDK · YALE UNIVERSITY · PI MICHAEL H NATHANSON · 1986 to 2026
$7.4MIn vivo Pathway Discovery in Autosomal Dominant Polycystic Kidney DiseaseRC2DK120534 · NIDDK · YALE UNIVERSITY · PI CAPLAN, MICHAEL J., SHULMAN, GERALD I · 2019 to 2023
$6.6MINSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32GM007324 · NIGMS · YALE UNIVERSITY · PI BENNETT, ANTON M · 1987 to 2022
$6.2MStructure, function, and disease biology of MICU1/MICU2R01AR071942 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Zenon Grabarek, Vamsi Krishna Mootha · 2018 to 2026
$4.1MEffects of Hepatic Acetyl-CoA Carboxylase Inhibition on NAFLD and Hepatic Insulin ResistanceR01DK113984 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2017 to 2021
$3.7MInteractions between neutrophils and cholangiocytes in alcoholic hepatitisR01AA028765 · NIAAA · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2021 to 2025
$3.5MDevelopment of Controlled Release Mitochondrial Protonophore (CRMP) as a Novel Treatment for Type-2 Diabetes and Non-Alcoholic Steatohepatitis in Dysmetabolic Non-Human PrimatesR01DK119968 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2019 to 2024
$2.7MNCATS NIH HHS UL1 TR001863NIAAA NIH HHS R01 AA028765NIAMS NIH HHS R01 AR071942NIDDK NIH HHS F30 DK131846NIDDK NIH HHS F31 DK126362NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK113984NIDDK NIH HHS R01 DK116774NIDDK NIH HHS R01 DK119968NIDDK NIH HHS R01 DK133143NIDDK NIH HHS R01 DK135645NIDDK NIH HHS RC2 DK120534NIDDK NIH HHS T32 DK007356NIDDK NIH HHS U24 DK059635NIGMS NIH HHS T32 GM007324NIGMS NIH HHS T32 GM136651
Abstract
To examine the roles of mitochondrial calcium Ca
Indexed as
Calcium-Calmodulin-Dependent Protein Kinase Type 2CytosolGluconeogenesisLipolysisLiverAnimalsCalciumCalcium ChannelsMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondria, LiverOxidation-ReductionCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium ChannelscalciumCAMKIIfat oxidationglucose oxidationisocitrate dehydrogenase fluxmetabolic dysfunction-associated steatotic liver diseasemitochondriamitochondrial calcium uniporterQ-Fluxsuccinate dehydrogenase fluxtricarboxylic acid cycletype 2 diabetesα-ketoglutarate dehydrogenase flux
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.