Evidence map›Paper›PMID 39153159›Full record

ArticleMolecular neurobiology2025

Single-Nucleus Landscape of Glial Cells and Neurons in Alzheimer's Disease.

Mengru Lu, Jiaxin Li, Qi Huang, Daniel Mao, Grace Yang, Yating Lan, Jingyi Zeng, Mika Pan, Shengliang Shi, Donghua Zou

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mengru Lu *Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No 166 Daxuedong Road, Nanning, Guangxi, 530007, China.
Jiaxin Li *Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Qi Huang *Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No 166 Daxuedong Road, Nanning, Guangxi, 530007, China.
Daniel Mao *Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA.
Grace YangState College Area High School, State College, PA, 16801, USA.
Yating LanDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No 166 Daxuedong Road, Nanning, Guangxi, 530007, China.
Jingyi ZengDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No 166 Daxuedong Road, Nanning, Guangxi, 530007, China.
Mika PanDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No 166 Daxuedong Road, Nanning, Guangxi, 530007, China.
Shengliang ShiDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No 166 Daxuedong Road, Nanning, Guangxi, 530007, China. ssl_1964@163.com.
Donghua ZouDepartment of Neurology, The Second Affiliated Hospital of Guangxi Medical University, No 166 Daxuedong Road, Nanning, Guangxi, 530007, China. zoudonghua@gxmu.edu.cn.

Funding

Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation 2024GXNSFAA010121Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation 2024GXNSFDA010001National Natural Science Foundation of China 32060189the Innovation Project of Guangxi Graduate Education YCSW2024241
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease with a projected significant increase in incidence. Therefore, this study analyzed single-nucleus AD data to provide a theoretical basis for the clinical development and treatment of AD. We downloaded AD-related monocyte data from the Gene Expression Omnibus database, annotated cells, compared cell abundance between groups, and investigated glial and neuronal cell biological processes and pathways through functional enrichment analysis. Furthermore, we constructed a global regulatory network for AD based on cell communication and ecological analyses. Our findings revealed increased abundance of Capping Protein Regulator And Myosin 1 linker 1 (CARMIL1)

Indexed as

Alzheimer DiseaseCell NucleusNeurogliaNeuronsCell CommunicationGene Regulatory NetworksHumansAlzheimer’s diseaseCell abundanceNeuroinflammationOxidative stressSingle-nucleus RNA sequencing

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.