Evidence map›Paper›PMID 39153133›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025

Clinical outcomes of conduction system pacing compared to biventricular pacing in patients with mid-range ejection fraction.

Jiaojiao Tang, Nathan W Kong, Andrew Beaser, Zaid Aziz, Srinath Yeshwant, Cevher Ozcan, Roderick Tung, Gaurav A Upadhyay

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Conduction System Pacing Versus Biventricular Cardiac Resynchronization in HFmrEF: A Systematic Review and Meta-Analysis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiaojiao TangCenter for Arrhythmia Care, Heart and Vascular Institute, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 9024, Chicago, IL, 60637, USA.
Nathan W KongDivision of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Andrew BeaserCenter for Arrhythmia Care, Heart and Vascular Institute, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 9024, Chicago, IL, 60637, USA.
Zaid AzizCenter for Arrhythmia Care, Heart and Vascular Institute, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 9024, Chicago, IL, 60637, USA.
Srinath YeshwantCenter for Arrhythmia Care, Heart and Vascular Institute, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 9024, Chicago, IL, 60637, USA.
Cevher OzcanCenter for Arrhythmia Care, Heart and Vascular Institute, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 9024, Chicago, IL, 60637, USA.
Roderick TungCenter for Arrhythmia Care, Heart and Vascular Institute, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 9024, Chicago, IL, 60637, USA.
Gaurav A UpadhyayCenter for Arrhythmia Care, Heart and Vascular Institute, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 9024, Chicago, IL, 60637, USA. upadhyay@uchicago.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a paucity of data comparing conduction system pacing (CSP) to biventricular pacing (BiVP) in patients with heart failure (HF) with mid-range left ventricular ejection fraction (LVEF).

objectiveCompare the clinical outcomes of patients with mid-range LVEF undergoing CSP versus BiVP.

methodsPatients with mid-range LVEF (> 35 to 50%) undergoing CSP or BiVP were retrospectively identified. Lead performance, LVEF, HF hospitalization, and clinical composite outcome including upgrade to cardiac resynchronization therapy and mortality were compared.

resultsA total of 36 patients (20 BiVP, 16 CSP--14 His bundle pacing, 4 left bundle branch area pacing) were analyzed. The mean age was 73 ± 15, 44% were female, and the mean LVEF was 42 ± 5%. Procedural and fluoroscopy time was comparable between the two groups. QRS duration was significantly shorter for the CSP group compared to the BiVP group (P < 0.001). During a mean follow-up of 47 ± 36 months, no significant differences were found in thresholds or need for generator change due to early battery depletion. LVEF improved in both groups (41.5 ± 4.5% to 53.9 ± 10.9% BiVP, P < 0.001; 41.6 ± 5.3% to 52.5 ± 8.3% CSP, P < 0.001). There were no significant differences in HF hospitalizations (P = 0.71) or clinical composite outcomes (P = 0.07).

conclusionAmong patients with HF with moderately reduced ejection fraction, CSP appears associated with similar improvements in LVEF and had similar clinical outcomes as BiVP in mid-term follow-up.

Indexed as

Cardiac Pacing, ArtificialCardiac Resynchronization TherapyHeart Conduction SystemHeart FailureStroke VolumeAgedFemaleHumansMaleRetrospective StudiesTreatment OutcomeConduction system pacingHeart failureHis bundle pacingLeft bundle branch area pacingMid-range EF

Identifiers

PMID39153133

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.