Evidence map›Paper›PMID 39153086›Full record

ArticleBrain structure & function2024

Spatial-temporal representation of the astroglial markers in the developing human cortex.

A Kharlamova, Yu Krivova, A Proshchina, O Godovalova, D Otlyga, E Andreeva, M Shachina, E Grushetskaya, S Saveliev

Abstract read
PubMed Publisher
In one paragraph

Article in Brain structure & function, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A KharlamovaAvtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", Tsyurupy St., 3, Moscow, Russia, 117418. grossulyar@gmail.com.
Yu KrivovaAvtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", Tsyurupy St., 3, Moscow, Russia, 117418.
A ProshchinaAvtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", Tsyurupy St., 3, Moscow, Russia, 117418.
O GodovalovaAvtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", Tsyurupy St., 3, Moscow, Russia, 117418.
D OtlygaAvtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", Tsyurupy St., 3, Moscow, Russia, 117418.
E AndreevaMoscow Regional Research Institute of Obstetrics and Gynecology, Pokrovka St., 22A, Moscow, Russia, 101000.
M ShachinaMoscow Regional Research Institute of Obstetrics and Gynecology, Pokrovka St., 22A, Moscow, Russia, 101000.
E GrushetskayaAvtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", Tsyurupy St., 3, Moscow, Russia, 117418.
S SavelievAvtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", Tsyurupy St., 3, Moscow, Russia, 117418.

Funding

Russian Scientific Foundation # 22-15-00172 #22-25-00370
6 · The paper itself

Abstract

Specific spatiotemporal patterns of the normal glial differentiation during human brain development have not been thoroughly studied. Immunomorphological studies on postmortem material have remained a basic method for human neurodevelopmental studies so far. The main problem for the immunohistochemical research of astrogliogenesis is that now there are no universal astrocyte markers, that characterize the whole mature astrocyte population or precursors at each stage of development. To define the general course of astrogliogenesis in the developing human cortex, 25 fetal autopsy samples at the stages from eight postconceptional weeks to birth were collected for the immunomorphological analysis. Spatiotemporal immunoreactivity patterns with the panel of markers (ALDH1L1, GFAP, S100, SOX9, and Olig-2), related to glial differentiation were described and compared. The early S100 + cell population of ventral origin was described as well. This S100 + cell distribution deviated from the SOX9-immunoreactivity pattern and was similar to the Olig-2 one. In the given material the dorsal gliogenic wave was characterized by ALDH1L1-, GFAP-, and S100-immunoreactivity manifestation in the dorsal proliferative niche at the end of the early fetal period. The time point of dorsal astrogliogenesis was agreed upon not later than the 17 GW stage. ALDH1L1 + , GFAP + , S100 + , and SOX9 + cell expansion patterns from the ventricular and subventricular zones to the intermediate zone, subplate, and cortical plate were described at the end of early fetal, middle, and late fetal periods. The ALDH1L1-, GFAP-, and S100-immunoreactivity patterns were shown to be not completely identical.

Indexed as

AstrocytesBiomarkersCerebral CortexGlial Fibrillary Acidic ProteinSOX9 Transcription FactorAldehyde Dehydrogenase 1 FamilyCell DifferentiationFemaleFetusHumansNerve Tissue ProteinsOligodendrocyte Transcription Factor 2Retinal DehydrogenaseS100 ProteinsAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanBiomarkersGFAP protein, humanGlial Fibrillary Acidic ProteinNerve Tissue ProteinsOLIG2 protein, humanOligodendrocyte Transcription Factor 2Retinal DehydrogenaseS100 ProteinsSOX9 protein, humanSOX9 Transcription FactorAstrocyteCerebral cortexGlial markersGliogenesisHuman brain developmentHuman fetuses

Identifiers

PMID39153086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.