Evidence map›Paper›PMID 39153025›Full record

SynthesisAIDS and behavior2024

Meta-analysis of Pregnancy Events in Biomedical HIV Prevention Trials in Sub-Saharan Africa: Implications for Gender Transformative Trials.

Lara Lorenzetti, Nhi Dinh, Cason Whitcomb, Andres Martinez, Manju Chatani, Breanne Lievense, Definate Nhamo, Catherine Slack, Natalie Eley, Kathleen MacQueen

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in AIDS and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lara LorenzettiBehavioral, Epidemiological and Clinical Sciences Division, Durham, NC, FHI 360, USA. llorenzetti@fhi360.org.ORCID http://orcid.org/0000-0003-4758-7390
Nhi DinhBehavioral, Epidemiological and Clinical Sciences Division, Durham, NC, FHI 360, USA.ORCID http://orcid.org/0000-0002-9887-7729
Cason WhitcombBehavioral, Epidemiological and Clinical Sciences Division, Durham, NC, FHI 360, USA.ORCID http://orcid.org/0000-0002-5234-8178
Andres MartinezBehavioral, Epidemiological and Clinical Sciences Division, Durham, NC, FHI 360, USA.ORCID http://orcid.org/0000-0002-0763-1978
Manju ChataniAVAC, New York, NY, USA.
Breanne LievenseAVAC, New York, NY, USA.
Definate NhamoPangaea Zimbabwe, Harare, Zimbabwe.ORCID http://orcid.org/0000-0002-6058-5237
Catherine SlackSchool of Law, University of KwaZulu-Natal, Pietermaritzburg, South Africa.ORCID http://orcid.org/0000-0002-6608-0248
Natalie EleyBehavioral, Epidemiological and Clinical Sciences Division, Durham, NC, FHI 360, USA.
Kathleen MacQueenBehavioral, Epidemiological and Clinical Sciences Division, Durham, NC, FHI 360, USA.ORCID http://orcid.org/0000-0003-2436-4741

Funding

USAID No. AID-OAA-A-16-00031
6 · The paper itself

Abstract

Historically, pregnant and lactating populations (PLP) have been excluded or disenrolled from biomedical HIV prevention trials, despite being more likely to acquire HIV during pregnancy and the post-partum period. We conducted a meta-analysis of pregnancy events in biomedical HIV prevention trials in sub-Saharan Africa to support trialists moving toward more inclusive clinical and implementation studies. We searched peer-reviewed literature reporting pregnancy events and contraceptive requirements in HIV prevention trials between 2001 and 2022. We hypothesized four variables to explain variation: contraceptive requirements, study start year, study product, and sub-region. We fit a meta-analytic model to estimate individual effect sizes and sampling variances, then conducted sub-group analyses to assess moderating effects. We identified 38 references for inclusion, across which the proportion of pregnancy events was 8% (95% confidence interval [CI]: 6-10%) with high heterogeneity (I

Indexed as

HIV InfectionsPregnancy Complications, InfectiousAfrica South of the SaharaClinical Trials as TopicContraceptionContraceptive AgentsFemaleHumansPregnancyContraceptive AgentsBiomedical HIV prevention trialsEligibility criteriaGender transformativeMeta-analysisPregnancy

Identifiers

PMID39153025
PMCPMC11471715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.