ArticleJACC. Cardiovascular imaging2024
Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque.
Article in JACC. Cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Multidomain risk profiles and documented polyvascular involvement across atherosclerotic vascular beds.American journal of preventive cardiology · 2026Article
- Use of a polygenic risk score to enhance early detection of coronary atherosclerosis.American journal of preventive cardiology · 2026Article
- Genetic and clinical risk factors for recurrent events among patients with coronary artery disease.American journal of preventive cardiology · 2026Article
- Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study.EClinicalMedicine · 2026Article
- Exercise-Induced Coronary Remodeling and the Atherosclerotic Paradox in Endurance Athletes: Toward a Unified Mechanobiological Framework.Journal of functional morphology and kinesiology · 2026Review
- Improving Polygenic Risk Prediction for Atherosclerotic Cardiovascular Disease in East Asian Populations.JACC. Asia · 2026Review
- Performance of Cardiovascular Polygenic Risk Scores in Carotid Stenosis Identification.medRxiv : the preprint server for health sciences · 2026Article
- Screening for high coronary plaque volume in primary prevention: integration of multi-omics and coronary calcium scoring into cardiovascular risk assessment.American journal of preventive cardiology · 2026Article
- Article
- Association of a polygenic risk score with coronary atherosclerotic burden in clinical CT angiograms.medRxiv : the preprint server for health sciences · 2026Article
- Coronary Computed Tomography and Artificial Intelligence-based Plaque Analysis.Current atherosclerosis reports · 2026Review
- Use of artificial intelligence in the multimodal evaluation of ischemia in patients with hypertrophic cardiomyopathy.The international journal of cardiovascular imaging · 2026Article
- Precision cardiovascular medicine with big data and AI.NPJ digital medicine · 2026Review
- Polygenic risk score predicts presence of subclinical atherosclerosis in first-degree relatives of patients with premature coronary artery disease.American journal of preventive cardiology · 2026Article
- Genomic Perspective on Heterogeneity of Organs and Body Aging.Aging cell · 2026Review
- Advancing cardiovascular risk assessment.Cardiovascular research · 2025Article
- Coronary atherosclerosis in athletes: emerging concepts and preventive strategies.European heart journal · 2025Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundThe longitudinal relation between coronary artery disease (CAD) polygenic risk score (PRS) and long-term plaque progression and high-risk plaque (HRP) features is unknown.
objectivesThe goal of this study was to investigate the impact of CAD PRS on long-term coronary plaque progression and HRP.
methodsPatients underwent CAD PRS measurement and prospective serial coronary computed tomography angiography (CTA) imaging. Coronary CTA scans were analyzed with a previously validated artificial intelligence-based algorithm (atherosclerosis imaging-quantitative computed tomography imaging). The relationship between CAD PRS and change in percent atheroma volume (PAV), percent noncalcified plaque progression, and HRP prevalence was investigated in linear mixed-effect models adjusted for baseline plaque volume and conventional risk factors.
resultsA total of 288 subjects (mean age 58 ± 7 years; 60% male) were included in this study with a median scan interval of 10.2 years. At baseline, patients with a high CAD PRS had a more than 5-fold higher PAV than those with a low CAD PRS (10.4% vs 1.9%; P < 0.001). Per 10 years of follow-up, a 1 SD increase in CAD PRS was associated with a 0.69% increase in PAV progression in the multivariable adjusted model. CAD PRS provided additional discriminatory benefit for above-median noncalcified plaque progression during follow-up when added to a model with conventional risk factors (AUC: 0.73 vs 0.69; P = 0.039). Patients with high CAD PRS had an OR of 2.85 (95% CI: 1.14-7.14; P = 0.026) and 6.16 (95% CI: 2.55-14.91; P < 0.001) for having HRP at baseline and follow-up compared with those with low CAD PRS.
conclusionsPolygenic risk is strongly associated with future long-term plaque progression and HRP in patients suspected of having CAD.
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