Evidence map›Paper›PMID 39152335›Full record

ArticleJournal of hematopathology2024

Simultaneous merkel cell carcinoma and acute myeloid leukaemia: A diagnostic challenge.

Juan López-Pérez, Mª Paz Garrastazul-Sánchez, Ana Valenzuela-Caballero, Lidia Atienza-Cuevas, Mª Inmaculada Gardelegui-Pérez, Raquel de la Varga-Martínez

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In one paragraph

Article in Journal of hematopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juan López-PérezServicio de Inmunología. UGC Hematología e Inmunología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Mª Paz Garrastazul-SánchezServicio de Hematología. UGC Hematología e Inmunología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Ana Valenzuela-CaballeroServicio de Inmunología. UGC Hematología e Inmunología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Lidia Atienza-CuevasUGC de Anatomía Patológica, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Mª Inmaculada Gardelegui-PérezServicio de Hematología y Hemoterapia, Hospital de la Línea de la Concepción, Cádiz, Spain.
Raquel de la Varga-MartínezServicio de Inmunología. UGC Hematología e Inmunología, Hospital Universitario Puerta del Mar, Cádiz, Spain. raquel.varga.sspa@juntadeandalucia.es.ORCID http://orcid.org/0000-0001-5767-0695

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Merkel cell carcinoma is a very aggressive primary skin tumour with a high risk of local recurrences and lymphatic and distant metastases. The frequent association between this carcinoma and other skin tumour and lymphoid malignancies, its similar cellular morphology with leukocytes, and limited infiltration in bone marrow constituted a challenging diagnosis. We report an unusual case of an 82-year-old male who simultaneously presented Merkel cell carcinoma and acute myeloid lymphoma. The diagnosis was established through flow cytometry, immunohistochemical studies and next generation sequencing (NGS) analysis. Flow cytometry allowed for the differentiation of the two cell populations in bone marrow aspirate, which was crucial to the diagnosis of Merkel cell carcinoma and acute myeloid leukaemia (AML), after confirmed by immunohistochemistry. AML could be classified based on NGS results. Following diagnosis, the patient received palliative care and died 50 days later. immunophenotypic analysis by flow cytometry and Immunohistochemical study was crucial to establish the diagnosis of simultaneous affection of Merkel cell carcinoma and hematologic disorder.

Indexed as

Carcinoma, Merkel CellLeukemia, Myeloid, AcuteSkin NeoplasmsAged, 80 and overFatal OutcomeFlow CytometryHumansImmunohistochemistryMaleNeoplasms, Multiple PrimaryAcute myeloid leukaemiaFlow cytometryMerkel cell carcinomaOncohematology

Identifiers

PMID39152335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.