Trial reportNature metabolism2024
Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study.
Trial report in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02399423 (The GlasVEGAS Study), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The GlasVEGAS Study (Glasgow Visceral & Ectopic Fat With Weight Gain in South AsianS) - Does Adipose Tissue Expandibility Differ Between South Asians and Europeans and Does This Contribute to Differences in Cardio-metabolic Disease Risk?
Who cites it
14 citing papers in PubMed.
- Greater Glycaemic Responses to Bodyweight Change in South Asians Than White Europeans at High Risk of Type 2 Diabetes.Diabetes, obesity & metabolism · 2026Trial
- GLP-1, GIP, and Glucagon Excursions During a Mixed Meal Tolerance Test in Young and Lean South Asians Versus Europids.Diabetes, obesity & metabolism · 2026Trial
- Biopsychosocial risk factors for Alzheimer's disease and related dementias in UK immigrants from the Middle East and North Africa (MENA).medRxiv : the preprint server for health sciences · 2026Article
- Ectopic fat distribution and its correlation with insulin resistance indices in non-obese individuals with type 2 diabetes.Acta diabetologica · 2026Article
- Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes.International journal of epidemiology · 2026Article
- Adversity, adiposity, nutrition and metabolic well-being in multi-ethnic Asia.Nature metabolism · 2026Review
- HDL protein composition differs between young white European and South Asian men before and after weight gain.Clinical science (London, England : 1979) · 2025Article
- Differences in tissue-specific insulin resistance between South Asian and Nordic women with prediabetes after gestational diabetes.Diabetologia · 2025Article
- Single-Cell Transcriptomic Profiling of Longissimus Dorsi and Biceps Femoris Muscles in Kazakh Horses Reveals Cellular Heterogeneity and Myogenic Regulation.Animals : an open access journal from MDPI · 2025Article
- South Asians and cardiometabolic health: A framework for comprehensive care for the individual, community, and population - An American society for preventive cardiology clinical practice statement.American journal of preventive cardiology · 2025Article
- Lessons Learned From Epidemiology of Type 2 Diabetes in South Asians: Kelly West Award Lecture 2024.Diabetes care · 2025Article
- Adipose tissue quantity, distribution and pathology and its relationship with type-2 diabetes, insulin resistance and other clustering disease risk in South Asians: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Circulating short chain fatty acid levels and body composition in type 2 diabetes mellitus.International journal of medical sciences · 2025Observational
- The South Asian phenotype: greater clarity would help to improve cardiometabolic health.The Lancet regional health. Southeast Asia · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
South Asians (SAs) develop type 2 diabetes at lower body mass index values than white Europeans (WEs). This basic human experimental study aimed to compare the metabolic consequences of weight gain in SA and WE men without overweight or obesity. Fourteen SAs and 21 WEs had assessments of body composition, metabolic responses to mixed-meal ingestion, cardiorespiratory fitness and physical activity, and a subcutaneous abdominal adipose tissue biopsy, before and after 4-6 weeks of overfeeding to induce 5-7% weight gain. Here we show that body mass index and whole-body adipose tissue volume increases similarly between ethnic groups, but SAs gain less lean tissue. SAs experience a substantially greater decrease in insulin sensitivity compared with WEs (38% versus 7% decrease, P = 0.009), have fewer small (37.1% versus 60.0%, P = 0.003) and more large (26.2% versus 9.1%, P = 0.005) adipocytes at baseline and have a smaller decrease in very small adipocytes with weight gain (-0.1% versus -1.9%, P < 0.0001). Ethnic differences in adipocyte morphology are associated with SA's greater adverse metabolic changes with weight gain. ClinicalTrials.gov registration: NCT02399423 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.