ArticleScientific reports2024
Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain microstructural alterations in COVID-19: a systematic review of diffusion weighted imaging studies.Brain imaging and behavior · 2026Pooled it
- COVID-19 Is Airborne AIDS: Provocative Oversimplification, Emerging Science, or Something in Between?AJPM focus · 2026Review
- Early-Phase Oral Antiviral Use and Post-COVID-19 Condition in Outpatients.JAMA network open · 2026Observational
- Global neural oscillations underlie performance variability and attentional state fluctuations in humans.Scientific reports · 2026Article
- A comprehensive multimodal MRI and EEG-TMS dataset on the impact of parietal cortex inhibition on decision-making under ambiguity.Data in brief · 2026Article
- Review
- Coupling between neural oscillations and white matter integrity reveals cognitive computational profiles following COVID-19.Scientific reports · 2025Article
- Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025Review
- Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing.Scientific reports · 2025Article
- White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis.Scientific reports · 2025Article
- Neurologic symptoms as a hallmark of glymphatic alteration in recovered patients with COVID-19.BMC neurology · 2025Article
- Clinic evaluation of cognitive impairment in post-COVID syndrome: Performance on legacy pen-and-paper and new digital cognitive tests.Brain, behavior, & immunity - health · 2025Article
- White matter changes in recovered COVID-19 patients: insights from DTI, DKI, and NODDI metrics.Frontiers in neurology · 2025Article
- Lateral prefrontal theta oscillations causally drive a computational mechanism underlying conflict expectation and adaptation.Nature communications · 2024Article
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Authors and funding
21 authors.
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Abstract
Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms and risk factors underlying these alterations remain elusive. Given the significant global incidence of COVID-19, identifying factors that can distinguish individuals at risk of developing brain alterations is crucial for prioritizing follow-up care. Here, we report findings from a sample of patients consisting of 73 adults with a mild to moderate SARS-CoV-2 infection without signs of respiratory failure and 27 with infections attributed to other agents and no history of COVID-19. The participants underwent cognitive screening, a decision-making task, and MRI evaluations. We assessed for the presence of anosmia and the requirement for hospitalization. Groups did not differ in age or cognitive performance. Patients who presented with anosmia exhibited more impulsive alternative changes after a shift in probabilities (r = - 0.26, p = 0.001), while patients who required hospitalization showed more perseverative choices (r = 0.25, p = 0.003). Anosmia correlated with brain measures, including decreased functional activity during the decision-making task, thinning of cortical thickness in parietal regions, and loss of white matter integrity. Hence, anosmia could be a factor to be considered when identifying at-risk populations for follow-up.
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