Evidence map›Paper›PMID 39152141›Full record

ArticleNature communications2024

An enantioselective and modular platform for C4'-modified nucleoside analogue synthesis enabled by intramolecular trans-acetalizations.

Thirupathi Nuligonda, Gautam Kumar, Jason W Wang, Dinithi Rajapaksha, Ismael A Elayan, Ramiz Demir, Neil J Meanwell, Sherrie F Wang, Lara K Mahal, Alex Brown and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Clickable RNA via 4'-Bioconjugate chemistry · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thirupathi Nuligonda *Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Gautam Kumar *Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Jason W WangDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Dinithi RajapakshaDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Ismael A ElayanDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-7161-5155
Ramiz DemirDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0001-6435-7883
Neil J MeanwellDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Sherrie F WangDepartment of Mathematics & Science, North Island College, Courtenay, BC, Canada.
Lara K MahalDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-4791-8524
Alex BrownDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-5384-9222
Michael W MeanwellDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada. meanwell@ualberta.ca.ORCID 0000-0002-4217-8478

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C4'-modified nucleoside analogues continue to attract global attention for their use in antiviral drug development and oligonucleotide-based therapeutics. However, current approaches to C4'-modified nucleoside analogues still involve lengthy (9-16 steps), non-modular routes that are unamenable to library synthesis. Towards addressing the challenges associated with their syntheses, we report a modular 5-step process to a diverse collection of C4'-modified nucleoside analogues through a sequence of intramolecular trans-acetalizations of readily assembled polyhydroxylated frameworks. Overall, the 2-3 fold reduction in step-count compares favorably to even recently reported biocatalytic approaches and should ultimately enable new opportunities in drug design around this popular chemotype.

Indexed as

NucleosidesAcetalsAntiviral AgentsDrug DesignStereoisomerismAcetalsAntiviral AgentsNucleosides

Identifiers

PMID39152141
PMCPMC11329634

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.