ArticleNature communications2024
Mechanistic conformational and substrate selectivity profiles emerging in the evolution of enzymes via parallel trajectories.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Development of a Potent Engineered Microbial Lipase for the Treatment of Exocrine Pancreatic Insufficiency.Gastro hep advances · 2026Article
- Exploring the Evolution-Coupling Hypothesis: Do Enzymes' Performance Gains Correlate with Increased Dissipation?Entropy (Basel, Switzerland) · 2025Article
- Discovery of highly active kynureninases for cancer immunotherapy through protein language model.Nucleic acids research · 2025Article
- Mechanistic Insights into the Stimulatory Effect of Melanogenesis of 4-Methylcoumarin Derivatives in B16F10 Melanoma Cells.International journal of molecular sciences · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
Laboratory evolution studies have demonstrated that parallel evolutionary trajectories can lead to genetically distinct enzymes with high activity towards a non-preferred substrate. However, it is unknown whether such enzymes have convergent conformational dynamics and mechanistic features. To address this question, we use as a model the wild-type Homo sapiens kynureninase (HsKYNase), which is of great interest for cancer immunotherapy. Earlier, we isolated HsKYNase_66 through an unusual evolutionary trajectory, having a 410-fold increase in the k
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