Evidence map›Paper›PMID 39152127›Full record

ArticleNature communications2024

Mapping the structure-function relationship along macroscale gradients in the human brain.

Evan Collins, Omar Chishti, Sami Obaid, Hari McGrath, Alex King, Xilin Shen, Jagriti Arora, Xenophon Papademetris, R Todd Constable, Dennis D Spencer and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Evan CollinsDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA. evanc@mit.edu.ORCID 0000-0003-0774-6975
Omar ChishtiDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1789-0030
Sami ObaidDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Hari McGrathDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0037-4761
Alex KingDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Xilin ShenDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Jagriti AroraDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Xenophon PapademetrisDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
R Todd ConstableDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5661-9521
Dennis D SpencerDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Hitten P ZaveriDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7830-0052

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Network analysis for epilepsy surgeryR01NS109062 · NINDS · YALE UNIVERSITY · PI EID, TORE, ZAVERI, HITTEN P · 2019 to 2022
$1.5M
NCATS NIH HHS UL1 TR001863NINDS NIH HHS R01 NS109062U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) NIH RO1 NS109062
6 · The paper itself

Abstract

Functional coactivation between human brain regions is partly explained by white matter connections; however, how the structure-function relationship varies by function remains unclear. Here, we reference large data repositories to compute maps of structure-function correspondence across hundreds of specific functions and brain regions. We use natural language processing to accurately predict structure-function correspondence for specific functions and to identify macroscale gradients across the brain that correlate with structure-function correspondence as well as cortical thickness. Our findings suggest structure-function correspondence unfolds along a sensory-fugal organizational axis, with higher correspondence in primary sensory and motor cortex for perceptual and motor functions, and lower correspondence in association cortex for cognitive functions. Our study bridges neuroscience and natural language to describe how structure-function coupling varies by region and function in the brain, offering insight into the diversity and evolution of neural network properties.

Indexed as

BrainBrain MappingAdultCognitionFemaleHumansMagnetic Resonance ImagingMaleMotor CortexNatural Language ProcessingNerve NetStructure-Activity RelationshipWhite Matter

Identifiers

PMID39152127
PMCPMC11329792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.