Evidence map›Paper›PMID 39152116›Full record

ArticleNutrition & diabetes2024

Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice.

Suraphan Panyod, Wei-Kai Wu, Ya-Chi Hsieh, Yea-Jing Tseng, Sin-Yi Peng, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Advances in essential oils for metabolic diseases.Frontiers in endocrinology · 2025
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Suraphan Panyod *Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.ORCID 0000-0001-8998-375X
Wei-Kai Wu *Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, ROC.ORCID 0000-0002-9476-8998
Ya-Chi HsiehInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
Yea-Jing TsengInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
Sin-Yi PengInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
Rou-An ChenInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
Huai-Syuan HuangInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
Yi-Hsun ChenDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Ting-Chin David ShenDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chi-Tang HoDepartment of Food Science, Rutgers University, New Brunswick, NJ, USA.
Chun-Jen LiuDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Hsiao-Li ChuangNational Laboratory Animal Center, National Applied Research Laboratories, Taipei, Taiwan, ROC.
Chi-Chang HuangGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City, Taiwan, ROC.
Ming-Shiang WuDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. mingshiang@ntu.edu.tw.ORCID 0000-0002-1940-6428
Lee-Yan SheenInstitute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC. lysheen@ntu.edu.tw.ORCID 0000-0001-5541-652X

Funding

Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 109-2314-B-002-064-MY3Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 109-2327-B-002-005Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 110-2327-B-002-007Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 111-2327-B-002-008Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 111-2628-B-002-047
6 · The paper itself

Abstract

backgroundDiet and gut microbiota contribute to non-alcoholic steatohepatitis (NASH) progression. High-fat diets (HFDs) change gut microbiota compositions, induce gut dysbiosis, and intestinal barrier leakage, which facilitates portal influx of pathogen-associated molecular patterns including lipopolysaccharides (LPS) to the liver and triggers inflammation in NASH. Current therapeutic drugs for NASH have adverse side effects; however, several foods and herbs that exhibit hepatoprotection could be an alternative method to prevent NASH.

methodsWe investigated ginger essential oil (GEO) against palm oil-containing HFDs in LPS-injected murine NASH model.

resultsGEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; and increased antioxidant catalase, glutathione reductase, and glutathione levels to prevent NASH. GEO alleviated hepatic inflammation through mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome and LPS/Toll-like receptor four (TLR4) signaling pathways. GEO further increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance.

conclusionThis study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.

Indexed as

Gastrointestinal MicrobiomeInflammasomesLipopolysaccharidesMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinNon-alcoholic Fatty Liver DiseaseOils, VolatileSignal TransductionToll-Like Receptor 4Zingiber officinaleAnimalsDiet, High-FatDisease Models, AnimalDisease ProgressionLiverMaleInflammasomesLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseOils, VolatileTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID39152116
PMCPMC11329514

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.