ArticleNature communications2024
Focal seizures induce spatiotemporally organized spiking activity in the human cortex.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Assessing Strengths and Limitations of Magnetoencephalography Source Imaging With Intracerebral EEG.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Seize the Data: A User-Friendly GUI for High-Resolution Analysis of Seizure Dynamics in HD-MEA Recordings.eNeuro · 2026Article
- Propofol-induced loss of responsiveness reorganizes cortical traveling waves in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Magnetic resonance identification tags for ultra-flexible electrodes.Nature communications · 2026Article
- The role of the parahippocampal cortex in memory consolidation for scenes.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Co-activation of interictal epileptiform discharges localizes seizure onset zone and fluctuates with brain state.Brain communications · 2025Article
- Interictal spikes and evoked cortical potentials share common spatiotemporal constraints in human epilepsy.Frontiers in network physiology · 2025Article
- Reproducibility of temporally evolving seizure patterns and network connectivity in focal epilepsy.Frontiers in neurology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Epileptic seizures are debilitating because of the clinical symptoms they produce. These symptoms, in turn, may stem directly from disruptions in neural coding. Recent evidence has suggested that the specific temporal order, or sequence, of spiking across a population of cortical neurons may encode information. Here, we investigate how seizures disrupt neuronal spiking sequences in the human brain by recording multi-unit activity from the cerebral cortex in five male participants undergoing monitoring for seizures. We find that pathological discharges during seizures are associated with bursts of spiking activity across a population of cortical neurons. These bursts are organized into highly consistent and stereotyped temporal sequences. As the seizure evolves, spiking sequences diverge from the sequences observed at baseline and become more spatially organized. The direction of this spatial organization matches the direction of the ictal discharges, which spread over the cortex as traveling waves. Our data therefore suggest that seizures can entrain cortical spiking sequences by changing the spatial organization of neuronal firing, providing a possible mechanism by which seizures create symptoms.
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