Article in Biochimica et biophysica acta. General subjects, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
David R LamsonBiomanufacturing Research Institute and Technology Enterprise, USA.
Michael TarpleyBiomanufacturing Research Institute and Technology Enterprise, USA.
Kezia AddoBiomanufacturing Research Institute and Technology Enterprise, USA.
Xiaojia JiBiomanufacturing Research Institute and Technology Enterprise, USA.
Dina Abu RabeBiomanufacturing Research Institute and Technology Enterprise, USA; INBS PhD Program, USA.
Ben EheBiomanufacturing Research Institute and Technology Enterprise, USA.
Mark HughesBiomanufacturing Research Institute and Technology Enterprise, USA.
Ginger R SmithBiomanufacturing Research Institute and Technology Enterprise, USA.
Laura R DayeBiomanufacturing Research Institute and Technology Enterprise, USA.
David L MussoBiomanufacturing Research Institute and Technology Enterprise, USA.
Weifan ZhengBiomanufacturing Research Institute and Technology Enterprise, USA; Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC 27707, USA.
Kevin P WilliamsBiomanufacturing Research Institute and Technology Enterprise, USA; Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC 27707, USA. Electronic address: kpwilliams@nccu.edu.
Funding
Understanding Perceptions of HIV Risk, PrEP, and PrEP use among African American Women Attending an HBCUU54MD012392 · NIMHD · NORTH CAROLINA CENTRAL UNIVERSITY · PI Cherise Baldwin Harrington · 2017 to 2026
$38.1M
Scientific Mentoring and Research Experiences CoreU54AA030451 · NIAAA · NORTH CAROLINA CENTRAL UNIVERSITY · PI XIAOHE YANG · 2022 to 2026
$6.4M
Addressing the Biology of Health Disparities by Targeting Geographical Ancestry-driven Variants of ImmunityR01MD017405 · NIMHD · NORTH CAROLINA CENTRAL UNIVERSITY · PI KIMBRO, KEVIN SEAN, NAVARRO, HERNAN A · 2021 to 2025
$3.4M
Identification of Specific Antagonists that Bind Hedgehog and Block its ActivityR15CA159209 · NCI · NORTH CAROLINA CENTRAL UNIVERSITY · PI WILLIAMS, KEVIN PETER · 2011 to 2011
Sonic hedgehog (Shh) is a morphogen with important roles in embryonic development and in the development of a number of cancers. Its activity is modulated by interactions with binding partners and co-receptors including heparin and heparin sulfate proteoglycans (HSPG). To identify antagonists of Shh/heparin binding, a diverse collection of 34,560 chemicals was screened in single point 384-well format. We identified and confirmed twenty six novel small molecule antagonists with diverse structures including four scaffolds that gave rise to multiple hits. Nineteen of the confirmed hits blocked binding of the N-terminal fragment of Shh (ShhN) to heparin with IC
Indexed as
Hedgehog ProteinsHeparinSmall Molecule LibrariesAnimalsCell LineHumansMiceProtein BindingSignal TransductionZinc Finger Protein GLI1Hedgehog ProteinsHeparinSHH protein, humanSmall Molecule LibrariesZinc Finger Protein GLI1C3H10T1/2HeparinHigh-throughput screeningSAGSonic hedgehog
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays. · full record | OpenQuestion