ArticleNeurology2024
Temporal and Spatial Clustering of Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.
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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Neuroimaging Markers Associated With Recurrent Stroke in Intracerebral Hemorrhage and Atrial Fibrillation: Secondary Analysis of PRESTIGE-AF.Neurology · 2025Trial
- Disease Progression in Iatrogenic Cerebral Amyloid Angiopathy.Neurology · 2026Article
- Associations of chronic kidney disease with recurrent stroke in patients with intracerebral haemorrhage.European stroke journal · 2026Article
- Hiding in Plain Sight: Inflammation in Iatrogenic Cerebral Amyloid Angiopathy.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Cerebrospinal Fluid Biomarkers Profiling in Cerebral Amyloid Angiopathy and Relationship With Disease Phenotypes.Journal of the American Heart Association · 2025Article
- Cerebral Amyloid Angiopathy-Related Inflammation in Iatrogenic Cerebral Amyloid Angiopathy.European journal of neurology · 2025Article
- Location and Timing of Recurrent, Nontraumatic Intracerebral Hemorrhage.JAMA neurology · 2025Article
- MRI-Based Prediction of Macrovascular Causes of Intracerebral Hemorrhage: The MACRO Score.Neurology · 2024Observational
- Posterior confluent white matter hyperintensities and intracerebral hemorrhage recurrence risk in patients with cerebral amyloid angiopathy.Frontiers in neurologyArticle
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Authors and funding
21 authors.
Simon Fandler-HöflerFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0001-9043-0378
Gareth AmblerFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0002-5322-7327
Gargi BanerjeeFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0003-0190-7782
Philip S NashFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0003-2428-1575
Lena ObergottsbergerFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0009-0001-5583-7647
Gerit WünschFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0009-0007-3076-3390
Christian KissFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.
Linda FabischFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.
Markus KneihslFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0002-6334-9432
Wenpeng ZhangFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0001-8748-3962
Hatice OzkanFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0003-1656-4559
Martina LocatelliFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0002-5019-964X
Yang DuFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0002-0805-6282
Larysa PanteleienkoFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.
Rom MendelFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.
Kitti ThiankhawFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.
Robert J SimisterFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0003-0578-6711
Hans Rolf JägerFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0002-6403-4184
Christian EnzingerFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0001-9764-7617
Thomas GattringerFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0002-6065-6576
David J WerringFrom the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.ORCID 0000-0003-2074-1861
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCerebral amyloid angiopathy (CAA)-associated lobar intracerebral hemorrhage (ICH) has a high risk of recurrence, but the underlying mechanisms remain uncertain. We, therefore, aimed to characterize patterns of recurrent ICH.
methodsWe investigated early recurrent ICH (≥1 recurrent ICH event within 90 days of the index event) and ICH clusters (≥2 ICH events within 90 days at any time point) in 2 large cohorts of consecutive patients with first-ever ICH and available MRI.
resultsIn 682 included patients (median age 68 years, 40.3% female, median follow-up time 4.1 years), 18 (2.6%) had an early recurrent ICH, which was associated with higher age and CAA. In patients with probable CAA, the risk of early recurrent ICH was increased 5-fold within the first 3 months compared with during months 4-12 (hazard ratio 5.41, 95% CI 2.18-13.4) while no significant difference was observed in patients without CAA. In patients with an ICH cluster, we observed spatial clustering (recurrent ICH within close proximity of index ICH in 63.0%) and a tendency for multiple sequential hemorrhages (≥3 ICH foci within 3 months in 44.4%). DISCUSSION: Our data provide evidence of both temporal and spatial clustering of ICH in CAA, suggesting a transient and localized active bleeding-prone process.
Indexed as
Cerebral Amyloid AngiopathyCerebral HemorrhageMagnetic Resonance ImagingRecurrenceAgedAged, 80 and overCluster AnalysisCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedTime Factors
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