ArticleScience advances2024
Epinephrine promotes breast cancer metastasis through a ubiquitin-specific peptidase 22-mediated lipolysis circuit.
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Adipose triglyceride lipase driven lipolysis as a targetable metabolic vulnerability in prostate cancer with intrinsic metabolic inflexibility.British journal of cancer · 2026Article
- Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- A malignant symbiosis: The neuro-metabolic symphony rewires the tumor microenvironment.Neoplasia (New York, N.Y.) · 2026Review
- Depression remodels tumor microenvironment to drive tumor progression: Bio-behavioural signalling pathways and clinical interventions.Journal of advanced research · 2026Review
- SIRT2-mediated deacetylation activates USP22 catalytic function for PD-L1 protein stabilization and tumor immune escape.The Journal of clinical investigation · 2026Article
- B7-H3 interaction with cMet enhances lipolysis to drive malignant progression of glioma via pSTAT3-ATGL axis.Journal of translational medicine · 2026Article
- Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling.Science advances · 2026Article
- The neuroimmune axis in breast cancer: from mechanistic insights to clinical applications.BMC medicine · 2026Review
- IFFO1 inhibits breast cancer by coordinating mitochondrial fission and fatty acid synthesis via the LaminA/C-PGC1α axis.Oncogenesis · 2026Article
- piR-1170 drives brain metastasis and immune evasion via WTAP-mediated m6A methylation reprogramming in triple-negative breast cancer.Molecular cancer · 2026Article
- The mechanisms and therapeutic advances of interactions between breast cancer and cardiovascular diseases.Frontiers in pharmacology · 2026Review
- Stress Biology in Cancer: Neuroendocrine-Immune Mechanisms Linking Tumor Progression to Translational Interventions.Cancer communications (London, England) · 2026Review
- Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets.MedComm · 2025Review
- Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming.World journal of clinical oncology · 2025Review
- NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ubiquitination in cancer: mechanisms and therapeutic opportunities.Cancer communications (London, England) · 2025Review
- Sympathetic nervous system in tumor progression and metabolic regulation: mechanisms and clinical potential.Journal of translational medicine · 2025Review
- Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer.Biomedicines · 2025Review
- Decoding the metastatic nexus: how chronic stress reprograms neuroendocrine-metabolic-microbiome circuits to fuel tumor metastasis.American journal of cancer research · 2025Review
- Chronic Psychological Stress in Oncogenesis: Multisystem Crosstalk and Multimodal Interventions.Research (Washington, D.C.) · 2025Review
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Authors and funding
25 authors.
Yuanzhang ZhouDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0000-0002-9806-9254
Peng ChuDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0000-0002-5371-3018
Ya WangDepartment of Breast Surgery, First Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
Na LiDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0009-0002-3469-5579
Qiong GaoDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0009-0002-8416-6026
Shengnan WangDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Juncheng WeiDepartment of Pathology & Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Guoqing XueDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0000-0002-1888-4276
Yue ZhaoDepartment of Clinical Laboratory, Dalian Municipal Central Hospital, Dalian 116000, China.ORCID 0009-0006-8886-4314
Huijun JiaDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0000-0003-3463-1575
Jiankun SongDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0009-0008-0830-1832
Yue ZhangDepartment of Breast Surgery, First Affiliated Hospital of Dalian Medical University, Dalian 116044, China.ORCID 0009-0006-4758-4359
Yujie PangDepartment of Breast Surgery, First Affiliated Hospital of Dalian Medical University, Dalian 116044, China.ORCID 0009-0001-5648-7685
Houyu ZhuDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0009-0001-8548-7895
Jia SunDalian College of Pharmacy, Dalian Medical University, Dalian 116044, China.ORCID 0009-0003-3234-2128
Suxian MaDalian College of Pharmacy, Dalian Medical University, Dalian 116044, China.ORCID 0009-0009-7335-3716
Chen SuDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0009-0005-6018-8441
Bingjin HuDalian College of Pharmacy, Dalian Medical University, Dalian 116044, China.ORCID 0009-0006-1645-1430
Zhuoyue ZhaoDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0009-0001-7459-1726
Hui ZhangDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Janice LuDepartment of Medicine & Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jian WangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.ORCID 0000-0002-8116-7691
Hongjiang WangDepartment of Breast Surgery, First Affiliated Hospital of Dalian Medical University, Dalian 116044, China.ORCID 0000-0002-1060-1737
Zhaolin SunDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0009-0003-0180-3286
Deyu FangDepartment of Pathology & Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-4211-2751
Funding
Novel Role of Hepatic SEL1L-HRD1 ERAD in FGF21 Gene TranscriptionR01DK120330 · NIDDK · UNIVERSITY OF VIRGINIA · PI Deyu Fang, Ling Qi · 2018 to 2026
$4.9MA deubiquitination module controls Treg adaptation to tumor microenvironmentR01CA257520 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU, ZHANG, BIN · 2021 to 2025
$2.8MRegulation of Rhythmic m6A RNA Modification by ER‐associated DegradationR01DK126908 · NIDDK · WAYNE STATE UNIVERSITY · PI FANG, DEYU, ZHANG, KEZHONG · 2021 to 2024
$2.2MTargeting a Treg deubiquitinase in antitumor immune therapyR01CA232347 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU · 2018 to 2022
$1.7MNCI NIH HHS R01 CA232347NCI NIH HHS R01 CA257520NIDDK NIH HHS R01 DK120330NIDDK NIH HHS R01 DK126908
Abstract
Chronic stress-induced epinephrine (EPI) accelerates breast cancer progression and metastasis, but the molecular mechanisms remain unclear. Herein, we found a strong positive correlation between circulating EPI levels and the tumoral expression of ubiquitin-specific peptidase 22 (USP22) in patients with breast cancer. USP22 facilitated EPI-induced breast cancer progression and metastasis by enhancing adipose triglyceride lipase (ATGL)-mediated lipolysis. Targeted USP22 deletion decreased ATGL expression and lipolysis, subsequently inhibiting EPI-mediated breast cancer lung metastasis. USP22 acts as a bona fide deubiquitinase for the
Indexed as
Breast NeoplasmsEpinephrineLipolysisUbiquitin ThiolesteraseAcyltransferasesAnimalsCell Line, TumorFemaleForkhead Box Protein O1Gene Expression Regulation, NeoplasticHumansLipaseLung NeoplasmsMiceNeoplasm MetastasisPhosphorylationAcyltransferasesEpinephrineForkhead Box Protein O1LipasePNPLA2 protein, humanUbiquitin ThiolesteraseUsp22 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.