Evidence map›Paper›PMID 39150780›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Mice lacking

Michalina Hanzel, Kayla Fernando, Susan E Maloney, Zachi Horn, Shiaoching Gong, Kärt Mätlik, Jiajia Zhao, H Amalia Pasolli, Søren Heissel, Joseph D Dougherty and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Mice lackingProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Michalina HanzelLaboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.
Kayla FernandoNeurobiology Department, Duke University, Durham, NC 27710.
Susan E MaloneyDepartment of Psychiatry and the Intellectual and Developmental Disabilities Research Center, Washington University Medical School, St. Louis, MO 63130.ORCID 0000-0001-5585-4722
Zachi HornLaboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.
Shiaoching GongHelen and Robert Appel Alzheimer's Disease Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10021.
Kärt MätlikLaboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.ORCID 0000-0003-1777-5614
Jiajia ZhaoLaboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.ORCID 0000-0003-3046-5362
H Amalia PasolliElectron Microscopy Resource Center, The Rockefeller University, New York, NY 10065.
Søren HeisselProteomics Resource Center, The Rockefeller University, New York, NY 10065.
Joseph D DoughertyDepartment of Psychiatry and the Intellectual and Developmental Disabilities Research Center, Washington University Medical School, St. Louis, MO 63130.ORCID 0000-0002-6385-3997
Court HullNeurobiology Department, Duke University, Durham, NC 27710.ORCID 0000-0002-0360-8367
Mary E HattenLaboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-9059-660X

Funding

Transforming Translational Science and Education to Benefit Human HealthUL1TR000043 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2012 to 2015
$26.8M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Canonical computations for motor learning by the cerebellar cortex micro-circuitR01NS112917 · NINDS · DUKE UNIVERSITY · PI LISBERGER, STEPHEN G, MEDINA, JAVIER F · 2019 to 2023
$6.4M
Role of ASTN2 in Cerebellar Circuit Function and ASD-related BehaviorsR01NS116089 · NINDS · ROCKEFELLER UNIVERSITY · PI HATTEN, MARY ELIZABETH, HULL, COURT A · 2021 to 2025
$3.1M
Cerebellar circuits for reward-based learningR01NS128054 · NINDS · DUKE UNIVERSITY · PI COURT A HULL · 2022 to 2026
$1.9M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) P50HD103525HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 5R01NS116089HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS128054 R01NS112917Leon Levy Foundation FellowshipNCATS NIH HHS UL1 TR000043NICHD NIH HHS P50 HD103525NINDS NIH HHS R01 NS112917NINDS NIH HHS R01 NS116089NINDS NIH HHS R01 NS128054Sigrid Juselius Foundation Fellowship
6 · The paper itself

Abstract

Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with

Indexed as

Autism Spectrum DisorderCerebellumMice, KnockoutPurkinje CellsAnimalsBehavior, AnimalDisease Models, AnimalMaleMembrane ProteinsMiceNerve Tissue ProteinsMembrane ProteinsNerve Tissue ProteinsASTN2autism spectrum disordercerebellumneurodevelopmental disorderPurkinje cell

Identifiers

PMID39150780
PMCPMC11348334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.