ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2024
Association between human leukocyte antigen class II-DR-DQ and narcolepsy: a case control study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The Impact of Antigen Presentation on BBB Disruption and Neuroinflammation.Physiology (Bethesda, Md.) · 2026Review
- Narcolepsy: immunity, neural circuitry, and brain network reconfiguration.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
STUDY
objectivesNarcolepsy is a neurologic disorder characterized by irresistible sleep attacks. Although its etiology is unknown, it is strongly associated with genetic variances in the human leukocyte antigen (HLA) complex. We investigated the association of HLA class II-DR-DQ alleles in a sample of patients with narcolepsy-cataplexy (narcolepsy type 1 [NT1]) and patients with narcolepsy without cataplexy (narcolepsy type 2) with a control group. Additionally, we compared demographic, clinical, and laboratory characteristics of patients with narcolepsy with or without the
methodsThis case control study included 21 patients with NT1 (56.8%), 16 patients with narcolepsy type 2 (43.2%), and 100 controls. Sequence-based typing identified HLA-
resultsIn the NT1 group, only 1 allele had a significantly higher frequency than in the narcolepsy type 2 group:
conclusionsThis study showed a strong association between HLA- CITATION: Bacelar A, Fernandez O, Paradella E, Rodrigues RN, de Castro Moreno CR, Alvarenga R. Association between human leukocyte antigen class II-DR-DQ and narcolepsy: a case control study.
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