Evidence map›Paper›PMID 39150588›Full record

ArticleInternational journal of colorectal disease2024

Vertical margin distance in T1 colorectal carcinoma resected by endoscopic submucosal dissection affects prognosis after additional surgery.

Fumiaki Tanino, Ken Yamashita, Shinji Nagata, Toshio Kuwai, Yuki Kamigaichi, Hidenori Tanaka, Yuzuru Tamaru, Hidehiko Takigawa, Naoki Asayama, Yuji Urabe and 2 more

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Fumiaki TaninoDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Ken YamashitaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. kenyama5@hiroshima-u.ac.jp.
Shinji NagataDepartment of Gastroenterology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Toshio KuwaiDepartment of Endoscopy, National Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Yuki KamigaichiDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Hidenori TanakaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Yuzuru TamaruDepartment of Endoscopy, National Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Hidehiko TakigawaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Naoki AsayamaDepartment of Gastroenterology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Yuji UrabeDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Fumio ShimamotoDepartment of Health Sciences, Hiroshima Cosmopolitan University, Hiroshima, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA vertical margin (VM) distance of < 500 µm is a risk factor for recurrence in patients with T1 colorectal carcinoma (CRC) resected by endoscopy. We aimed to determine the effects of the VM distance on the recurrence and prognosis of T1 CRC.

methodsWe enrolled 168 patients with T1 CRC who underwent additional surgery after endoscopic submucosal dissection (ESD) at multiple centers between 2008 and 2016. None of the patients were followed up for < 5 years. The enrolled 168 patients were classified into patients with VM distance of < 500 µm including positive VM (n = 72 [43%], VM distance < 500 µm group) and patients with VM distance of ≥ 500 µm (n = 96 [57%], VM distance ≥ 500 µm group). The clinicopathological features, recurrence rates, and prognoses were compared between the groups using propensity-score matching (PSM).

resultsTumors recurred in eight of the 168 patients (5%) with VM distance < 500 µm. After PSM, the rate of overall recurrence and local recurrence in the VM distance < 500 µm group were significantly higher than those in the VM distance ≥ 500 µm group. The 5-year recurrence-free survival rate was significantly higher in the VM distance ≥ 500 µm group than that in VM distance < 500 µm group after PSM (100% vs. 89%, p < 0.012).

conclusionsComplete en bloc resection of T1 CRC via ESD must include a sufficient amount of SM to reduce the risk of metastasis and recurrence after additional surgery.

Indexed as

Colorectal NeoplasmsEndoscopic Mucosal ResectionMargins of ExcisionNeoplasm Recurrence, LocalAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisColorectal cancerEndoscopic submucosal dissectionMetastasisRecurrenceVertical margin

Identifiers

PMID39150588
PMCPMC11329615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.