Evidence map›Paper›PMID 39150500›Full record

ArticlePflugers Archiv : European journal of physiology2024

BK channels promote action potential repolarization in skeletal muscle but contribute little to myotonia.

Chris Dupont, Brianna Blake, Andrew A Voss, Mark M Rich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Pharmacological therapy of non-dystrophic myotonias.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chris DupontDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH, 45435, USA.
Brianna BlakeDepartment of Biological Sciences, Wright State University, Dayton, OH, 45435, USA.
Andrew A VossDepartment of Biological Sciences, Wright State University, Dayton, OH, 45435, USA.
Mark M RichDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH, 45435, USA. mark.rich@wright.edu.ORCID 0000-0002-6956-5531

Funding

Novel Approaches to Therapy of Muscle Ion ChannelopathiesR01AR074985 · NIAMS · WRIGHT STATE UNIVERSITY · PI MARK M RICH · 2019 to 2026
$3.9M
Determining if there is a primary myopathy in Huntington's diseaseR15NS099850 · NINDS · WRIGHT STATE UNIVERSITY · PI VOSS, ANDREW ALVIN · 2018 to 2018
$455k
Treating Hyperkalemic Periodic ParalysisF30AR081675 · NIAMS · WRIGHT STATE UNIVERSITY · PI DUPONT, CHRISTOPHER · 2022 to 2025
$198k
NIAMS NIH HHS F30 AR081675NIAMS NIH HHS R01 AR074985NIH HHS AR074985NIH HHS AR081675NIH HHS NS099850NINDS NIH HHS R15 NS099850
6 · The paper itself

Abstract

Patients with myotonia congenita suffer from slowed relaxation of muscle (myotonia), due to hyperexcitability caused by loss-of-function mutations in the ClC-1 chloride channel. A recent study suggested that block of large-conductance voltage- and Ca

Indexed as

Action PotentialsLarge-Conductance Calcium-Activated Potassium ChannelsMuscle, SkeletalAnimalsChloride ChannelsMiceMice, Inbred C57BLMice, KnockoutMyotoniaMyotonia CongenitaChloride ChannelsLarge-Conductance Calcium-Activated Potassium ChannelsExcitationK+ channelMyotonia congenitaPotassiumt-tubule

Identifiers

PMID39150500
PMCPMC11461784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.