Evidence map›Paper›PMID 39150493›Full record

ArticleInflammopharmacology2024

Chemical characterization of the essential oil from the leaves of Eugenia flavescens DC. (Myrtaceae) and its potential in the treatment of pain, inflammation, and ethanol- and ethanol/HCL-induced gastric ulcers in mice.

Irivânia Fidelis da Silva Aguiar, Bruno Oliveira de Veras, João Victor de Oliveira Alves, Lais Ruanita Leopoldina Galvão, Wêndeo Kennedy Costa, Geovanna Maria de Medeiros Moura, Daniela Maria do Amaral Ferraz Navarro, Júlio César Ribeiro de Oliveira Farias de Aguiar, Weslley Felix de Oliveira, Maria Tereza Dos Santos Correia and 1 more

Abstract read
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Article in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Irivânia Fidelis da Silva AguiarDepartment of Biochemistry, Laboratory of Natural Products, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil. irivania.aguiar@ufpe.br.ORCID http://orcid.org/0000-0003-0070-7770
Bruno Oliveira de VerasDepartment of Biochemistry, Laboratory of Natural Products, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.
João Victor de Oliveira AlvesDepartment of Biochemistry, Laboratory of Natural Products, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.
Lais Ruanita Leopoldina GalvãoDepartment of Biochemistry, Laboratory of Natural Products, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.
Wêndeo Kennedy CostaDepartment of Biochemistry, Laboratory of Natural Products, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.
Geovanna Maria de Medeiros MouraDepartment of Biochemistry, Laboratory Chemistry and Function of Bioactive Proteins, Federal University of Rio Grande Do Norte, Natal, Rio Grande Do Norte, 59078-970, Brazil.
Daniela Maria do Amaral Ferraz NavarroDepartment of Chemistry, Center for Exact and Nature Sciences, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.
Júlio César Ribeiro de Oliveira Farias de AguiarDepartment of Chemistry, Center for Exact and Nature Sciences, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.
Weslley Felix de OliveiraDepartment of Biochemistry, Laboratory of Natural Products, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.
Maria Tereza Dos Santos CorreiaDepartment of Biochemistry, Laboratory of Natural Products, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.
Márcia Vanusa da SilvaDepartment of Biochemistry, Laboratory of Natural Products, Federal University of Pernambuco, Recife, Pernambuco, 50670-420, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eugenia flavescens is a species cultivated in Brazil for food purposes. Given the potential application of essential oils from plants of the genus Eugenia, this study was carried out to investigate the chemical composition, acute toxicity, antioxidant, antinociceptive, gastroprotective activities, and possible mechanisms of action of the essential oil from the leaves of E. flavescens (EOEf). The EOEf was extracted by hydrodistillation, and the chemical composition was obtained using gas chromatography-mass spectrometry. The antioxidant activity was evaluated, as well as the acute toxicity and the antinociceptive and anti-inflammatory effects in mice. In addition, the gastroprotective effect was investigated using an acute gastric lesion model, considering possible mechanisms of action. The major components found in the EOEf were guaiol (19.97%), germacrene B (12.53%), bicyclogermacrene (11.11%), and E-caryophyllene (7.53%). The EOEf did not cause signs of toxicity in the acute oral toxicity test and showed in vitro antioxidant activity with IC

Indexed as

AnalgesicsAnti-Inflammatory AgentsAntioxidantsEthanolEugeniaInflammationOils, VolatilePainPlant LeavesStomach UlcerAnimalsAnti-Ulcer AgentsBrazilFemaleMaleMiceAnalgesicsAnti-Inflammatory AgentsAntioxidantsAnti-Ulcer AgentsEthanolOils, VolatileBrazilCaryophylleneEssential oilFoodGrow cropsMedicine

Identifiers

PMID39150493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.